Results 51 to 60 of about 199,144 (206)

Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. [PDF]

, 2009
Ulcerative colitis is a chronic inflammatory disease of the colon that presents as diarrhea and gastrointestinal bleeding. We performed a genome-wide association study using DNA samples from 1,052 individuals with ulcerative colitis and preexisting data ...
Abraham, Clara, Achkar, Jean-Paul, Annese, Vito, Barmada, M Michael, Bayless, Theodore M, Bossa, Fabrizio, Brant, Steven R, Cho, Judy H, Daly, Mark J, Duerr, Richard H, Goyette, Philippe, Gregersen, Peter K, Griffiths, Anne M, Ippoliti, Andrew F, Kistner, Emily O, Klei, Lambertus, Lahaie, Raymond G, Latiano, Anna, Lee, Annette T, McGovern, Dermot PB, Paré, Pierre, Proctor, Deborah D, Regueiro, Miguel D, Rioux, John D, Roeder, Kathryn, Rotter, Jerome I, Schumm, L Philip, Scott, Regan, Silverberg, Mark S, Steinhart, A Hillary, Targan, Stephan R, Taylor, Kent D, Wu, Jing, Xu, Wei   +33 more
core  

β‐Glucuronidase‐Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity Through Depleting the Regenerative Epithelial Stem/Progenitor Pool

Advanced Science, EarlyView.
XLP mitigated CPT11 mucositis by suppressing GUS‐expressing microbes, notably L. reuteri, and diminishing bacterial GUS activity, consequently reducing SN38 accumulation to protect the intestinal epithelium. This preservation of the mucosal stem cell niche enabled rapid regeneration of secretory lineages such as mucin‐producing goblet cells, which ...
Bei Yue, Ruiyang Gao, Ling Zhao, Donghui Liu, Cheng Lv, Ziyi Wang, Fangbin Ai, Beibei Zhang, Zhilun Yu, Xiaolong Geng, Hao Wang, Kang Wang, Kaixian Chen, Chenghai Liu, Zhengtao Wang, Wei Dou   +15 more
wiley   +1 more source

On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease [PDF]

, 2010
Nitrite and nitrate are frequently used surrogate markers of nitric oxide (NO) production. Using rat models of acute and chronic DSS-induced colitis we examined the applicability of these and other NO-related metabolites, in tissues and blood, for the ...
Ahn, Alexandra B. Milsom, Andoh, Angelo, Aoi, Billiar, Bryan, Bryan, Brüne, Buffinton, Butler, Calvert, Carr, Cheng, Chris Andry, Collins, Cooper, D. Neil Granger, Danese, Danese, de Kok, Dijkstra, Eiserich, Feelisch, Finkel, Fumito Saijo, Godkin, Grisham, Guevara, Guihot, Guzy, Herulf, Ikeda, Jourd’heuil, Juan Rodriguez, Kapsoritakis, Kihara, Kimura, Kimura, Kleinbongard, Kolios, Krawisz, Krieglstein, Lundberg, Lundberg, Marina Ivanovic, Martin Feelisch, May, Miehsler, Murthy, Nathan S. Bryan, Nikolaus, Okayasu, Onderdonk, Osman, Ostanin, Pearson, Quera, Rachmilewitz, Reynolds, Rius, Roediger, Rousseaux, Rumi, Schopfer, Selena M. Bauer, Singer, Solem, Stucchi, Stuehr, Talbot, Taniguchi, Taylor, Terada, Thorsten Vowinkel, Togawa, Tsikas, van Faassen, Velayos, Vowinkel, Wang, Whiteman   +81 more
core   +1 more source

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui, Meng Yang, Chengli Yu, Haidong Zhang, Yuan Gong, Yang Hu, Yue Wang, Qingxin Yuan, An Pan, Jiepin Li, Yaowen Hu, Zecheng Jin, Xuemei Peng, Anyuan Wu, Junwei Wang, Qian Wang, Yinan Zhang, Lihong Hu   +17 more
wiley   +1 more source

COLITIS IN PNEUMONIA. [PDF]

The Lancet, 1921
n ...
openaire   +3 more sources

Endoscopic scores for inflammatory bowel disease in the era of 'mucosal healing'. old problem, new perspectives [PDF]

, 2016
The importance of the endoscopic evaluation in inflammatory bowel disease (IBD) management has been recognized for many years. However, the modalities for reporting endoscopic activity represent an ongoing challenge.
Corleto, Vito Domenico, DELLE FAVE, Gianfranco, Desideri, F, DI GIULIO, Emilio, Menasci, F, Pagnini, C   +5 more
core   +1 more source

Gut Microbiota Colonization in Early Life Influences Susceptibility to Adulthood Hepatic Lipid Accumulation in High‐Fat‐Diet‐Fed Mice

Advanced Science, EarlyView.
This study indicates that perinatal antibiotic exposure elevates susceptibility to high‐fat‐diet‐induced hepatic lipid accumulation via disrupting early‐life gut microbiota colonization. The decreased Lactobacillus colonization inhibits primary‐to‐secondary bile acid conversion, lowering secondary bile acids, enhancing adulthood intestinal lipid ...
Yan‐Yan Zhu, Xin Dong, Hao Zhou, Ze‐Yan Li, Bo Wang, Ya‐Ping Song, Zhi‐Bing Liu, Xue Lu, Yi‐Hao Zhang, Yichao Huang, Hua Wang, De‐Xiang Xu   +11 more
wiley   +1 more source

Ulcerative Colitis

New England Journal of Medicine, 2012
Ulcerative colitis is an idiopathic, chronic inflammatory disorder of the colonic mucosa, which starts in the rectum and generally extends proximally in a continuous manner through part of, or the entire, colon; however, some patients with proctitis or left-sided colitis might have a caecal patch of inflammation.
Daniel, El Fassi, Claus H, Nielsen
openaire   +6 more sources

Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype: Results of a 25-year follow-up study [PDF]

, 2003
AIM: IBD is a systemic disease associated with a large number of extraintestinal manifestations (EIMs). Our aim was to determine the prevalence of EIMs in a large IBD cohort in Veszprem Province in a 25-year follow-up study.
Balogh, Zsuzsanna, Dávid, Gyula, Kuronya, Pál, Lakatos, László, Lakatos, Péter László, Pandur, Tünde, Tollas, Árpád   +6 more
core   +1 more source

Tailoring a Functional Synthetic Microbial Community Alleviates Fusobacterium nucleatum‐infected Colorectal Cancer via Ecological Control

Advanced Science, EarlyView.
The bottom‐up strategy based on multiomics data is used for the SynCom design, and it successfully inhibited F. nucleatum growth and achieved stable colonization in vivo. In addition, it promoted tryptophan metabolism and secondary bile acid conversion, reduced lipid accumulation, relieved microbiome disorder, decreased inflammatory reaction, and ...
Zhongkun Zhou, Mengyue Yang, Hong Fang, Baizhuo Zhang, Yunhao Ma, Yongyuan Li, Yingjie Liu, Zeying Cheng, Yuanchun Zhao, Zhenzhen Si, Hongmei Zhu, Peng Chen   +11 more
wiley   +1 more source