Results 81 to 90 of about 433,882 (351)
Canadian Journal of Gastroenterology and Hepatology, 2015 A series of clinical practice guidelines were recently developed by the Canadian Association of Gastroenterology (CAG) to provide clinicians with recommendations for the medical management of nonhospitalized ulcerative colitis (UC) patients.
A Hillary Steinhart, Aida Fernandes
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Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation
Science Advances, 2020 Gasdermin D in colonic macrophages controls cGAS-mediated inflammation, thereby protecting against the development of colitis. The functional relevance and mechanistic basis of the effects of the pyroptosis executioner Gasdermin D (GSDMD) on colitis ...
Chunmei Ma +9 more
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Advanced Science, EarlyView.An integral functional axis through which GPN and functional metabolites of Alistipes senegalensis can hydrolyze tryptophan into indoles. Furthermore, the Alistipes senegalensis‐indole‐AhR pathway is found to be associated with increased expression of tight junction‐associated proteins and activation of gut stem cells.
Dandan Wang +10 more
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Effects of Bifidobacterium bifidum in Mice Infected with Citrobacter rodentium
Microorganisms, 2019 In vitro and in vivo studies suggest that selected Bifidobacterium bifidum strains sustain intestinal homeostasis. This study aimed to examine whether the administration of B.
Bijun Wen +5 more
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Small RNA Toxin‐Assisted Evolution of GC‐Preferred ErCas12a for Enhanced Genome Targeting Range
Advanced Science, EarlyView.ErCas12a is engineered to target GC‐rich PAMs using a small RNA toxin‐aided positive screening system. The resulting variant, enErCas12a, exhibits an expanded PAM profile and facilitates efficient gene editing in both bacterial and mammalian cells, while preserving high targeting specificity for both canonical and non‐canonical PAM targets.
Zehua Chen +8 more
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The safety of vedolizumab for ulcerative colitis and Crohn's disease
Gut, 2016 Objective Vedolizumab is a gut-selective antibody to α4β7 integrin for the treatment of ulcerative colitis (UC) and Crohn's disease (CD). We report an integrated summary of the safety of vedolizumab.
J. Colombel +13 more
semanticscholar +1 more source
Advanced Science, EarlyView.Integrated single‐cell transcriptomic and metabolomic analyses reveal that MYC‐driven glycolysis activates the PI3K‐AKT‐FOXO1 pathway, disrupting Th17/Treg balance and promoting uveitis. MYC inhibition restores immune homeostasis and alleviates disease symptoms.
He Li +11 more
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Animal Research and One Health, EarlyView., 2023 In the present study, we created the weight gain models with Min and Yorkshire pigs and conducted the metagenomics and metabolomics of colon contents and transcriptomics of colon tissue. Further, we revealed the characteristics and functions of the colonic microbiota in Min and Yorkshire pigs and analyzed their interactions with the host. Overall, this
Xiaoyu Huang +6 more
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Scientific ReportsFecal samples were collected from 640 individuals in Korea, including 523 patients with IBD (223 with Crohn’s disease [CD] and 300 with ulcerative colitis [UC]) and 117 healthy controls.
Hyun Sik Kim +9 more
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Gut Pathogens, 2011 Background Probiotics have beneficial effects in rodent models of Clostridium difficile (C. diffiicle)-induced colitis. The spore forming probiotic strain Bacillus Coagulans GBI-30, 6086 (BC30) has demonstrated anti-inflammatory and immune-modulating ...
Fitzpatrick Leo R +4 more
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