aImperial College London, and Chelsea and Westminster Hospital, London, UK bDepartment of Gastroenterology and Hepatology, Chaim Sheba Medical Center, Tel Hashomer, Israel cDepartment of Medicine B, University Hospital Münster, Münster, Germany ...
M. Harbord+12 more
semanticscholar +1 more source
Surgery and Ulcerative Colitis [PDF]
The management of ulcerative colitis requires the collaboration of various teams looking after the patient and any decision regarding surgery should involve not only the patient and the surgeons but also various other professionals looking after the ...
Debono, Joseph, Gatt, Dennis
core
Automatic Estimation of Ulcerative Colitis Severity from Endoscopy Videos using Ordinal Multi-Instance Learning [PDF]
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by relapsing inflammation of the large intestine. The severity of UC is often represented by the Mayo Endoscopic Subscore (MES) which quantifies mucosal disease activity from endoscopy videos.
arxiv
The molecular landscape of colitis-associated carcinogenesis [PDF]
In spite of the well-established histopathological phenotyping of IBD-associated preneoplastic and neoplastic lesions, their molecular landscape remains to be fully elucidated. Several studies have pinpointed the initiating role of longstanding/relapsing
D'Inca', Renata+7 more
core +1 more source
On the Evaluation of Surrogate Markers in Real World Data Settings [PDF]
Shortcomings of randomized clinical trials are pronounced in urgent health crises, when rapid identification of effective treatments is critical. Leveraging short-term surrogates in real-world data (RWD) can guide policymakers evaluating new treatments.
arxiv
Helminths in the gastrointestinal tract 1 as modulators of immunity and pathology [PDF]
Helminth parasites are highly prevalent in many low- and middle-income countries, in which inflammatory bowel disease and other immunopathologies are less frequent than in the developed world.
Fleming, John O.+2 more
core +1 more source
Very long O-antigen chains enhance fitness during Salmonella-induced colitis by increasing bile resistance. [PDF]
Intestinal inflammation changes the luminal habitat for microbes through mechanisms that have not been fully resolved. We noticed that the FepE regulator of very long O-antigen chain assembly in the enteric pathogen Salmonella enterica serotype ...
Bäumler, Andreas J+6 more
core
Use of new, once-daily 5-aminosalicylic acid preparations in the treatment of ulcerative colitis. Is there anything new under the sun? [PDF]
5-aminosalicylate (5-ASA) agents remain the mainstay treatment in ulcerative colitis (UC). A number of oral 5-ASA agents are commercially available, including azobond pro-drugs, as well as delayed- and controlled-release forms of mesalazine.
Lakatos, Péter László
core +2 more sources
Deep Bayesian Active-Learning-to-Rank for Endoscopic Image Data [PDF]
Automatic image-based disease severity estimation generally uses discrete (i.e., quantized) severity labels. Annotating discrete labels is often difficult due to the images with ambiguous severity. An easier alternative is to use relative annotation, which compares the severity level between image pairs.
arxiv
Protection of hamsters from mortality by reducing fecal moxifloxacin concentration with DAV131A in a model of moxifloxacin-induced Clostridium difficile colitis [PDF]
BackgroundLowering the gut exposure to antibiotics during treatments can prevent microbiota disruption. We evaluated the effect of an activated charcoal-based adsorbent, DAV131A, on fecal free moxifloxacin concentration and mortality in a hamster model of moxifloxacin-induced C.
arxiv +1 more source