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Glucocorticoid-Mediated Extracellular Matrix Regulation: Implications for Precision Therapy [PDF]

open access: yesBiomedicines
Glucocorticoids (GCs) have revolutionized the treatment of multidisciplinary diseases. Recently, its role in severe infectious diseases has been revisited and discussed since the COVID-19 pandemic.
Yinghua Zhu   +3 more
doaj   +2 more sources

Hypercalcemia associated with dysgerminoma and elevation of calcitriol: A case report and review of the literature

open access: yesSAGE Open Medical Case Reports, 2022
We report on the case of a patient with dysgerminoma, a rare germ cell tumor, which showed hypercalcemia with an elevation of 1α,25-dihydroxycholecalciferol (calcitriol). A 27-year-old nulliparous woman presented with hypercalcemia during the examination
Natsuko Hara   +11 more
doaj   +1 more source

Ventricular fibrillation immediately after the treatment of Graves’ disease coexisting with atypical angina and long QT syndrome: a case report

open access: yesThyroid Research, 2022
Background Palpitations due to Graves’ disease are often caused by supraventricular arrhythmia. However, in rare cases, the background of coronary artery disease, genetic abnormalities, or channel abnormalities can cause ventricular fibrillation, which ...
Hajime Iwasaki   +8 more
doaj   +1 more source

Tofacitinib versus tocilizumab in the treatment of biological-naïve or previous biological-failure patients with methotrexate-refractory active rheumatoid arthritis

open access: yesRMD Open, 2021
Objectives To compare effectiveness between tofacitinib and tocilizumab treatments for biological disease-modifying antirheumatic drug (bDMARD)-naïve patients or previous bDMARD-failure patients with active rheumatoid arthritis (RA) refractory to ...
Yukitaka Ueki   +3 more
doaj   +1 more source

Serum progranulin level is a novel tool for monitoring disease activity of dermatomyositis with antimelanoma differentiation‐associated protein 5 antibodies

open access: yesJournal of Cutaneous Immunology and Allergy, 2021
Objectives Dermatomyositis (DM) is an autoimmune disease that presents with a wide variety of clinical manifestations. Patients with DM or clinically amyopathic dermatomyositis (CADM) with antimelanoma differentiation‐associated protein 5 (anti‐MDA5 ...
Asami Fujii   +6 more
doaj   +1 more source

The presence of neutrophil extracellular traps in different forms of pyoderma gangrenosum

open access: yesJournal of Cutaneous Immunology and Allergy, 2023
We demonstrated that there were abundant neutrophil extracellular traps (NETs) in the skin biopsies from various types of pyoderma gangrenosum (PG), based on the observation of extended and compact areas of immunolabeling of MPO and Cit H3 proteins.
Takaharu Ikeda   +6 more
doaj   +1 more source

Role of Collagen in Airway Mechanics

open access: yesBioengineering, 2021
Collagen is the most abundant airway extracellular matrix component and is the primary determinant of mechanical airway properties. Abnormal airway collagen deposition is associated with the pathogenesis and progression of airway disease.
Lumei Liu   +4 more
doaj   +1 more source

Congenital collagenopathies increased the risk of inguinal hernia developing and repair: analysis from a nationwide population-based cohort study

open access: yesScientific Reports, 2022
Herein, we aimed to explore whether male patients with congenital collagen diseases had a higher risk of inguinal herniation than patients without these diseases. Data were retrospectively collected from the National Health Insurance Research Database of
Hao-Han Chang   +4 more
doaj   +1 more source

Collagens and collagen-related diseases

open access: yesAnnals of Medicine, 2001
The collagen superfamily of proteins plays a dominant role in maintaining the integrity of various tissues and also has a number of other important functions. The superfamily now includes more than 20 collagen types with altogether at least 38 distinct polypeptide chains, and more than 15 additional proteins that have collagen-like domains.
Kari I. Kivirikko, Johanna Myllyharju
openaire   +3 more sources

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