Results 61 to 70 of about 480,477 (362)

Physically based 3D finite element model of a single mineralized collagen microfibril [PDF]

Journal of Theoretical Biology 301 (2012) 28-41, 2012
Mineralized collagen microfibrils in human bone provide its mechanical properties (stiffness, elasticity, ductility, energy dissipation and strength). However, detailed 3D finite element models describing the mechanical behaviour of the mineralized collagen microfibrils are still lacking.
arxiv   +1 more source

PU.1 controls fibroblast polarization and tissue fibrosis [PDF]

, 2019
Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue homeostasis and immune responses. In fibrotic diseases, fibroblasts synthesize abundant amounts of extracellular matrix, which induces scarring and organ failure.
Beyer, Christian, Boykin, David W., Butter, Falk, Chen, Chih-Wei, Daniel, Christoph, Dees, Clara, Distler, Jörg H. W., Distler, Oliver, Ekici, Arif, Finotto, Susetta, Gay, Steffen, Gelse, Kolja, Jüngel, Astrid, Kaplan, Mark H., Karouzakis, Emmanuel, Kiener, Hans P., Kremer, Andreas E., Kreuter, Alexander, Luber, Markus, Maier, Christiane, Matei, Alexandru-Emil, Naschberger, Elisabeth, Nutt, Stephen L., Pachera, Elena, Poon, Gregory M. K., Ramming, Andreas, Rauber, Simon, Schett, Georg, Soare, Alina, Sticherling, Michael, Stürzl, Michael, Uebe, Steffen, Weber, Stefanie, Wohlfahrt, Thomas   +33 more
core   +1 more source

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

The role of collagen in joint disorders: Applications in orthopedics, rheumatology, and sports medicine

Quality in Sport
Joint diseases are prevalent in orthopedic, rheumatological, and sports medicine fields, significantly impacting patients' quality of life. Collagen, a primary component of connective tissues, has emerged as a therapeutic agent for these conditions ...
Maria Wojcieszek, Julia Szałajska, Natalia Wierzejska, Mikołaj Domański, Barbara Kopczyńska, Oliwia Czyżniewska, Karolina Czupryńska, Karina Otręba   +7 more
doaj   +1 more source

Autophagy facilitates type I collagen synthesis in periodontal ligament cells

Scientific Reports, 2021
Autophagy is a lysosomal protein degradation system in which the cell self-digests its intracellular protein components and organelles. Defects in autophagy contribute to the pathogenesis of age-related chronic diseases, such as myocardial infarction and
Tomomi Nakamura, Motozo Yamashita, Kuniko Ikegami, Mio Suzuki, Manabu Yanagita, Jirouta Kitagaki, Masahiro Kitamura, Shinya Murakami   +7 more
doaj   +1 more source

A discrete-to-continuum model for the human cornea with application to keratoconus [PDF]

arXiv, 2023
We introduce a discrete mathematical model for the mechanical behaviour of a planar slice of human corneal tissue, in equilibrium under the action of physiological intraocular pressure (IOP). The model considers a regular (two-dimensional) network of structural elements mimicking a discrete number of parallel collagen lamellae connected by proteoglycan-
arxiv  

A Convolutional Neural Network for the Automatic Diagnosis of Collagen VI related Muscular Dystrophies

, 2019
The development of machine learning systems for the diagnosis of rare diseases is challenging mainly due the lack of data to study them. Despite this challenge, this paper proposes a system for the Computer Aided Diagnosis (CAD) of low-prevalence ...
Badosa, Carmen, Bazaga, Adrián, Jiménez-Mallebrera, Cecilia, Porta, Josep M., Roldán, Mònica   +4 more
core   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Telangiectatic Macules Spreading During More Than 30 Years: A Quiz

Acta Dermato-Venereologica
is missing (Quiz)
Italo Francesco Aromolo, Eleonora Di Michele, Francesca Laura Boggio, Angelo Cattaneo, Angelo Valerio Marzano   +4 more
doaj   +1 more source