Results 91 to 100 of about 2,225,266 (256)
Novel fusion protein-expressing lentiviral vectors ameliorate collagen induced arthritis [PDF]
, 2010 Collagen induced arthritis (CIA) is a mouse model of autoimmunity that closely resembles human rheumatoid arthritis (RA), a debilitating disease with no cure.
Ward, E.M.
core
Advanced Functional Materials, EarlyView.Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou +6 more
wiley +1 more source
The effect of Tumstatin and Canstatin-derived angiogenesis inhibitor peptides on FAK expression in animal model of breast cancer [PDF]
مجله دانشگاه علوم پزشکی گیلانBackground: Canstatin and Tumstatin are proteins derived from Collagen IV that inhibit tumor growth by preventing angiogenesis. Increased Focal Adhesion Kinase (FAK) expression may promote tumor progression and metastasis by stimulating cancer cell ...
Fatemeh Zamani, , , , , Ali Moradi
doaj
مجله كليه طب الكندي, 2016 Background: the difference in expression of type IV collagen in borderline tumors and ovarian carcinomas has been studied, but the association with adhesion molecules like CD44 have not gain enough interest.
Mohanad M. Abdul Ghany +2 more
doaj +1 more source
Collagen in arterial walls : Biomechanical aspects
, 2008 This chapter is written with an emphasis on the biomechanical role of collagen in normal and diseased arterial walls, its structural quantification and its consideration in material models including phenomena such as growth and remodeling.
Holzapfel, Gerhard A.,
core +1 more source
Advanced Functional Materials, EarlyView.This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu +14 more
wiley +1 more source
Anti-Fibrotic Effects of Astragaloside IV in Systemic Sclerosis
Cellular Physiology and Biochemistry, 2014 Objective: To evaluate the anti-fibrotic effects of Astragaloside IV in systemic sclerosis. Methods: Treated or untreated systemic sclerosis (SSc) and normal fibroblast isolated from corresponding pairs were utilized to detect expression of collagen and ...
Qing Qi +5 more
doaj +1 more source
, 2017 Degenerative retinal diseases are a leading cause of visual loss and irreversible blindness, particularly in the developed world. Retinal pigment cell (RPE) transplantation is nowadays considered the most promising therapeutic approach for certain ...
Minna Kellomäki +13 more
core +1 more source
Investigations on the functions ot "ten-1" during embryonic development in "Caenorhabditis" elegans [PDF]
, 2011 Teneurins are a family of phylogenetically conserved proteins. Their most prominent site of expression is the nervous system. Investigations on the expression pattern in vertebrates and invertebrates also revealed the importance for teneurins at sites of
Topf, Ulrike
core +1 more source
Bioinspired Hydrogels with Broadly Programmable Mechanics for Soft‐Tissue Interfaces
Advanced Functional Materials, EarlyView.Sea cucumber‐inspired gelatin hydrogels are formed by directional freezing and mechanically programmed through subsequent ionic treatment. Multiscale characterization and modeling link ion‐regulated chain interactions to directional load transfer within the aligned hierarchical architecture.
Youchao Teng +20 more
wiley +1 more source