Results 111 to 120 of about 2,225,266 (256)

Tribbles 3 Regulates the Fibrosis Cytokine TGF-β1 through ERK1/2-MAPK Signaling Pathway in Diabetic Nephropathy

Journal of Immunology Research, 2014
To reveal the expression and possible role of tribbles homolog 3 (TRB3) in the incidence of type 2 diabetic nephropathy, we used immunohistochemistry, real-time quantitative PCR, western blot analysis, and enzyme-linked immunosorbent assay (ELISA) to ...
Luwei Zhang, Jinhang Zhang, Xinnong Liu, Shengli Liu, Jun Tian   +4 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

The regulation of type I collagen gene expression in stromal fibroblast by breast tumour cells [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 110-135).Recent studies have revealed that interactions between tumour cells and the surrounding stroma play an important role in facilitating tumour growth and invasion.
Rose, Beverley Ann
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PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Identifying Mechanism-Based and Mechanism-Agnostic Interventions for Gould Syndrome ^†

Proceedings
Gould syndrome is caused by mutations in the genes encoding collagen IV alpha 1 (COL4A1) and 2 (COL4A2)—fundamental basement membrane components that form collagen α1α1α2(IV) heterotrimers [...]
Mao Mao, Cassandre Labelle-Dumais, Yoshihiro Ishikawa, Matthew D. Lebedev, Douglas B. Gould   +4 more
doaj   +1 more source

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

Advanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee, Yulseung Sung, Yeji Kim, Heesang Yang, Suyeon Pyo, Byeol Yun, Sung‐Joo Hwang   +6 more
wiley   +1 more source

Immunohistochemical Study of Type IV Collagen during Lense Development

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2010
BACKGROUND AND OBJECTIVE: Extracellular matrix (ECM) and basement membrane (BM) play important roles in many developmental processes during development and after birth.
M Jalali,, MR Nikravesh, AA Moeeni, MH Karimfar,, SH Mohammadi   +4 more
doaj  

Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
Multistimuli responsive dynamic covalent materials integrate reversible chemistry with the complex chemical, mechanical, and biochemical cues of regenerative environments. This review highlights chemical strategies based on orthogonal dynamic bonds, multicomponent networks, and hierarchical architectures to regulate mechanics, degradation, and ...
Saurabh Joshi, Matthew B. Baker, Dominik Schauenburg   +2 more
wiley   +1 more source

Inductive Role of Collagen Type IV During Nephrogenesis in Mice

Urology Journal, 2009
Introduction: During nephrogenesis, transition of mesenchyme to the epithelium of tubules and glomeruli occurs via the interaction of ureteral bud and metanephric mesenchyme.
Mehdi Jalali, Mohammad Reza Nikravesh, Abbas Ali Moeen, Mohammad Hassan Karimfar, Shahin Saidinejat, Shabnam Mohammadi, Houshang Rafighdoost   +6 more
doaj  

STRUCTURE AND MECHANICS OF STRETCHED COLLAGEN FIBRILS

, 2019
Collagen fibril are the smallest repeating units in load-bearing collagenous tissues such as tendon and bone, functioning as a microscopic stress mediators in mammalian bodies.
Peacock, Chris
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