Results 101 to 110 of about 21,718 (291)

Similar Ehlers–Danlos Syndrome Profiles Produced by Variants in Multiple Collagen Genes

DNA
Background: Despite increased attention to double-jointedness or joint hypermobility as seen in connective tissue dysplasias like Ehlers–Danlos syndrome, improved clinical DNA correlations are needed to reduce decadal delays in diagnosis.
Sahil S. Tonk, Golder N. Wilson
doaj   +1 more source

Improved Double-Nicking Strategies for COL7A1-Editing by Homologous Recombination

Molecular Therapy: Nucleic Acids, 2019
Current gene-editing approaches for treatment of recessive dystrophic epidermolysis bullosa (RDEB), an inherited, severe form of blistering skin disease, suffer from low efficiencies and safety concerns that complicate implementation in clinical settings.
Thomas Kocher, Roland N. Wagner, Alfred Klausegger, Christina Guttmann-Gruber, Stefan Hainzl, Johann W. Bauer, Julia Reichelt, Ulrich Koller   +7 more
doaj   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Reduced Skin Blistering in Experimental Epidermolysis Bullosa Acquisita After Anti-TNF Treatment

Molecular Medicine, 2016
Epidermolysis bullosa acquisita (EBA) is a difficult-to-treat subepidermal autoimmune blistering skin disease (AIBD) with circulating and tissue-bound anti-type VII collagen antibodies.
Misa Hirose, Anika Kasprick, Foteini Beltsiou, Katharina Schulze Dieckhoff, Franziska Sophie Schulze, Unni K J S R L Samavedam, Jennifer E Hundt, Hendri H Pas, Marcel F Jonkman, Enno Schmidt, Kathrin Kalies, Detlef Zillikens, Ralf J Ludwig, Katja Bieber   +13 more
doaj   +1 more source

Regulation of Type VII Collagen in Patients with Recessive Dystrophic Epidermolysis Bullosa [PDF]

, 2017
University of Minnesota Ph.D. dissertation.August 2017. Major: Microbiology, Immunology and Cancer Biology. Advisor: Tolar Jakub. 1 computer file (PDF); viii, 90 pages.Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a complex, life-threatening ...
Vanden Oever, Michael
core  

Type VII Collagen Gene Expression by Human Skin Fibroblasts and Keratinocytes in Culture: Influence of Donor Age and Cytokine Responses

, 1994
Type VII collagen is the predominant, if not the exclusive, component of the anchoring fibrils. In this study, we have examined the expression of the type VII collagen gene in human skin fibroblasts and keratinocytes in culture by Northern analyses and ...
Ryynänen, Jaana, Uitto, Jouni, Mauviel, Akin, Sollberg, Stephan, Chen, Yue Qiu   +4 more
core   +1 more source

Highly Flexible and Conformable ZnO/FeGa Magnetoelectric Heterostructures for Skin wound Healing

Advanced Science, EarlyView.
The magnetic field‐induced electric field generated by a highly flexile ZnO(piezoelectric)/FeGa(magnetostrictive) magnetoelectric heterostructure embedded in the low Young's modulus elastomer PDMS has been used to stimulate the wound healing processes.
Filippos Perdikos, Laia Bagur, Cristina Vaca, Aritz Lafuente, Joaquin Llacer‐Wintle, Bojan Ambrožič, Christina Stefani, Minsoo Kim, Goran Dražić, Darja Lisjak, Jordi Sort, Xiang‐Zhong Chen, Maria Jose Esplandiu, Salvador Pané, Carme Nogués, Josep Nogués, Andreu Blanquer, Borja Sepúlveda   +17 more
wiley   +1 more source

Laminin 511 E8 fragment promotes to form basement membrane-like structure in human skin equivalents

Regenerative Therapy
Introduction: Laminin 511 (LM511), a component of the skin basement membrane (BM), is known to enhance the adhesion of some cell types and it has been reported to affect cell behavior.
Hitomi Fujisaki, Takafumi Watanabe, Shusuke Yoshihara, Hideki Fukuda, Yasuko Tomono, Chisa Tometsuka, Kazunori Mizuno, Toshio Nishiyama, Shunji Hattori   +8 more
doaj   +1 more source

Ex Vivo COL7A1 Correction for Recessive Dystrophic Epidermolysis Bullosa Using CRISPR/Cas9 and Homology-Directed Repair

Molecular Therapy: Nucleic Acids, 2018
Recessive dystrophic epidermolysis bullosa is a rare and severe genetic skin disease resulting in blistering of the skin and mucosa. Recessive dystrophic epidermolysis bullosa (RDEB) is caused by a wide variety of mutations in COL7A1-encoding type VII ...
Araksya Izmiryan, Clarisse Ganier, Matteo Bovolenta, Alain Schmitt, Fulvio Mavilio, Alain Hovnanian   +5 more
doaj   +1 more source

Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-beta.

, 1994
A hallmark of systemic sclerosis (SSc) is the development of tissue fibrosis. Excessive production of several connective tissue components normally present in the dermis, including type I, III, V, and VI collagens as well as fibronectin and proteoglycans,
Christiano, Angela M., Varga, John, Jimenez, Sergio A., J Uitto, S A Jimenez, Uitto, Jouni, Iozzo, Renato V., Rudnicka, Lidia, L Rudnicka, A M Christiano, J Varga, R V Iozzo   +11 more
core   +1 more source