Results 91 to 100 of about 21,718 (291)
Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy
Advanced Science, EarlyView.Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee +11 more
wiley +1 more source
Can Type VII Collagen Injections Cure Dystrophic Epidermolysis Bullosa?
, 2020 I ntensive international efforts are being made to devise new molecular therapies for genetic skin diseases. 1 There are three major reasons for these efforts.
Leena Bruckner-Tuderman
core
Advanced Science, EarlyView.A developmentally inspired bioprinting approach enables the fabrication of pluripotent tissues that undergo shape‐morphing and in situ cardiac lineage specification. This method employs embedded bioprinting to deposit iPSCs within soft granular hydrogels to create pluripotent tissue constructs that undergo cell‐mediated shape morphogenesis.
Ankita Pramanick +8 more
wiley +1 more source
Anais Brasileiros de Dermatologia, 2005 As epidermólises bolhosas são dermatoses bolhosas congênitas que levam à formação de bolhas espontaneamente ou após trauma. São reconhecidos três grupos de da doença, de acordo com o segundo consenso internacional: simples, juncional e distrófica.
Thaiz Gava Rigoni Gürtler +2 more
doaj +1 more source
Collagen type VII α1 chain: A promising prognostic and immune infiltration biomarker of pancreatic cancer. [PDF]
Oncol Lett, 2023 Ding C, Yu Z, Li X, Zhu J, Dai M, He Q.
europepmc +1 more source
Endogenous but not exogenous type VII collagen increases LH3 expression in RDEB keratinocytes.
, 2015 (a) Retroviral delivery of type VII collagen in RDEB14 keratinocytes increases LH3 expression by immunofluorescence. (b) Type VII collagen increases LH3 in RDEB14 keratinocytes in cell extracts and conditioned media by immunoblotting. (c) siRNA depletion
Megan Riddle (797735) +15 more
core +1 more source
Advanced Science, EarlyView.This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma +10 more
wiley +1 more source
, 2002 peer-reviewedEpidermolysis bullosa acquisita is an autoimmune blistering disease of the skin characterized by IgG autoantibodies against type VII collagen.
WEIR, DONALD, KELLEHER, DERMOT P
core
Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis
Advanced Science, EarlyView.Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao +28 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv +8 more
wiley +1 more source