Results 41 to 50 of about 464,753 (192)
Immunological Medicine, 2019 Bullous pemphigoid (BP) is an organ-specific autoantibody-mediated autoimmune blistering skin disorder that tends to affect the elderly. Tense blister formation associated with itchy urticarial erythema is clinically observed in BP, and subepidermal ...
Wataru Nishie
doaj +1 more source
Coiled coils ensure the physiological ectodomain shedding of collagen XVII. [PDF]
J Biol Chem, 2012 α-Helical coiled coils, frequent protein oligomerization motifs, are commonly observed in vital proteins. Here, using collagen XVII as an example, we provide evidence for a novel function of coiled coils in the regulation of ectodomain shedding. Transmembrane collagen XVII, an epithelial cell surface receptor, mediates dermal-epidermal adhesion in the ...
Nishie W +4 more
europepmc +5 more sources
Context-Dependent Regulation of Collagen XVII Ectodomain Shedding in Skin [PDF]
The American Journal of Pathology, 2015 Pemphigoid is a common autoimmune blistering disorder in which autoantibodies target transmembrane collagen XVII (COL17), a component of hemidesmosomes in basal keratinocytes. The ectodomain of COL17 can be cleaved from the cell surface within the juxtamembranous extracellular NC16A domain, and, interestingly, certain autoantibodies of pemphigoid ...
Nishie, Wataru +8 more
openaire +3 more sources
Second harmonic generation confocal microscopy of collagen type I from rat tendon cryosections [PDF]
, 2006 We performed second harmonic generation (SHG) imaging of collagen in rat-tendon cryosections, using femtosecond laser scanning confocal microscopy, both in backscattering and transmission geometries.
Theodossiou, Theodossis A. +11 more
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Plasmid-Encoded Outer Membrane Protein YadA Mediates Specific Binding of Enteropathogenic Yersiniae to Various Types of Collagen [PDF]
, 1992 The plasmid-encoded outer membrane protein YadA of enteropathogenic yersiniae is associated with pathogenicity. Recently, collagen binding of YadA-positive yersiniae was reported without detailed characterization (L. Emödy, J. Heesemann, H. Wolf-Watz, M.
Emmerich, F. +4 more
core +1 more source
Orphanet Journal of Rare Diseases, 2021 Bullous pemphigoid (BP) is the most common autoimmune skin blistering disease characterized by autoimmunity against the hemidesmosomal proteins BP180, type XVII collagen, and BP230. To elucidate the genetic basis of susceptibility to BP, we performed the
Christian Schwarm +34 more
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Comparison of the solophenyl-red polarization method and the immunohistochemical analysis for collagen type III [PDF]
, 1992 In the present study, we have compared the staining pattern of the Solophenyl-Red 3 BL-method for the visualization of collagen type III with the immunohistochemical staining in serial sections from 7 skin wounds (wound age 3 days up to 4 weeks) to ...
Penning, R. +5 more
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Collagen XVII and TIMP-1 in epithelial cell migration [PDF]
, 2003 Collagen XVII (BP180) is a transmembrane component of hemidesmosomes, which connect basal keratinocytes to the basement membrane. The extracellular domain of collagen XVII is proteolytically shed from the cell surface and released to the extracellular ...
Parikka, M. (Mataleena)
core +1 more source
Frontiers in Immunology, 2022 Immune checkpoint inhibitors (ICI) induce T-cell-mediated antitumour responses. While ICI were initially successfully applied in metastasized melanoma, they are now approved for several tumour entities. Numerous autoimmune disorders have been reported to
Franziska Schauer +6 more
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Nature Communications, 2016 Tumour initiating cells (TICs) are anoikis resistant in suspension culture and they are critical for initiating tumorigenesis in vivo. Here, the authors show that these features are promoted by hemidesmosome-like structures enriched in laminin V and ...
Chen-Chi Liu +7 more
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