Results 21 to 30 of about 464,753 (192)
Junctional epidermolysis bullosa: genotype-phenotype correlations [PDF]
Vestnik Dermatologii i Venerologii, 2023 Junctional epidermolysis bullosa most commonly results from mutations in the LAMA3, LAMB3, LAMC2, COL17A1, ITGA6 and ITGB4 genes. Junctional epidermolysis bullosa is characterized by clinical heterogeneity.
Alexey A. Kubanov +3 more
doaj +1 more source
Efficacy of intradermal allogeneic fibroblast injections in junctional epidermolysis bullosa
Russian Open Medical Journal, 2022 Objective — to assess the efficacy and safety of intradermal injections of allogeneic fibroblasts into non-healing wounds in a patient with junctional epidermolysis bullosa.
Alexey A. Kubanov +4 more
doaj +1 more source
Collagen XVII deficiency alters epidermal patterning
Laboratory Investigation, 2022 Vertebrates exhibit patterned epidermis, exemplified by scales/interscales in mice tails and grooves/ridges on the human skin surface (microtopography). Although the role of spatiotemporal regulation of stem cells (SCs) has been implicated in this process, the mechanism underlying the development of such epidermal patterns is poorly understood.
Yunan Wang +11 more
openaire +3 more sources
BMC Cancer, 2023 Background Collagens are the major components of the extracellular matrix (ECM) and are known to contribute to tumor progression and metastasis. There are 28 different types of collagens each with unique functions in maintaining tissue structure and ...
Marina Crespo-Bravo +9 more
doaj +1 more source
The dysfunction of BP180/collagen XVII in keratinocytes promotes melanoma progression. [PDF]
Oncogene, 2019 BP180, also termed collagen XVII, is a hemidesmosomal transmembrane glycoprotein expressed in basal keratinocytes, and functions as a cell-matrix adhesion molecule in the dermal-epidermal junction of the skin. Its function, other than cell-matrix adhesion, remains unclear.
Hwang BJ +14 more
europepmc +6 more sources
Generation of a Functional Non-Shedding Collagen XVII Mouse Model: Relevance of Collagen XVII Shedding in Wound Healing [PDF]
Journal of Investigative Dermatology, 2016 Collagen XVII is a hemidesmosomal anchorage molecule of basal keratinocytes that promotes stable epidermal-dermal adhesion. One unique feature of collagen XVII is that its collagenous ectodomain is constitutively released from the cell surface by a disintegrin and metalloproteinases (ADAMs) through cleavage within its juxtamembranous linker domain. The
Jacków, Joanna +7 more
openaire +3 more sources
Characterisation of collagen-derived biomaterials [PDF]
, 2009 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University on 22 May 2009.One of the main problems in healthcare is the loss or failure of organs or tissues resulting from diseases, post-surgery complications ...
de Castro Bras, Lisandra
core +7 more sources
Anti-FcαRI Monoclonal Antibodies Resolve IgA Autoantibody-Mediated Disease
Frontiers in Immunology, 2022 Immunoglobulin A (IgA) is generally considered as a non-inflammatory regulator of mucosal immunity, and its importance in diversifying the gut microbiota is increasingly appreciated.
Amelie Bos +12 more
doaj +1 more source
The direct binding of collagen XVII and collagen IV is disrupted by pemphigoid autoantibodies [PDF]
Laboratory Investigation, 2019 The basement membrane zone (BMZ) is framed by hemidesmosomes and extracellular matrix (ECM) including collagen IV (COL4). Hemidesmosomes are multiprotein complexes that include collagen XVII (COL17). BMZ proteins can be targeted in autoimmune subepidermal blistering diseases, e.g., pemphigoid targeting COL17.
Mayumi Kamaguchi +7 more
openaire +2 more sources
Effect of 8 week endurance training on plasma and heart tissue collagen XVIII in male Wistar rats [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2012 Purpose: the aim of this study was to examine the effect of endurance training on plasma and heart tissue collagen XVII in male Wistar rats. Methods: 16 male Wistar rats (4-6 week old. 125-135 g weight) were randomly divided two groups: experimental (n=8)
حجت الله نیک بخت +2 more
doaj +1 more source