Results 11 to 20 of about 464,753 (192)

Neuronal collagen XVII is localized to lipofuscin granules

NeuroReport, 2010
We have earlier shown that collagen XVII is expressed by neurons in the human brain, although its exact intracellular location and function have remained unknown. In this study we have localized collagen XVII specifically to neuronal lipofuscin granules using electron microscopy in autopsy samples from the human brainstem.
Allan, Seppänen, Riitta, Miettinen, Irina, Alafuzoff   +2 more
openaire   +3 more sources

Hemizygosity for a Glycine Substitution in Collagen XVII: Unfolding and Degradation of the Ectodomain [PDF]

Journal of Investigative Dermatology, 2000
Defects of collagen XVII, a keratinocyte adhesion protein, are associated with epidermal detachment in junctional epidermolysis bullosa. Although some missense mutations in the collagen XVII gene COL17A1 have been described, the molecular mechanisms leading to disease have remained elusive in these cases. Here we assessed the biologic consequences of a
Tasanen, Kaisa, Floeth, Michaela, Schumann, Hauke, Bruckner-Tuderman, Leena   +3 more
openaire   +4 more sources

Type XVII collagen coordinates proliferation in the interfollicular epidermis [PDF]

eLife, 2017
Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement membrane zone. COL17 deficiency results in premature hair aging phenotypes and in junctional epidermolysis bullosa.
Mika Watanabe, Ken Natsuga, Wataru Nishie, Yasuaki Kobayashi, Giacomo Donati, Shotaro Suzuki, Yu Fujimura, Tadasuke Tsukiyama, Hideyuki Ujiie, Satoru Shinkuma, Hideki Nakamura, Masamoto Murakami, Michitaka Ozaki, Masaharu Nagayama, Fiona M Watt, Hiroshi Shimizu   +15 more
doaj   +4 more sources

Recombinant Type XVII Collagen Inhibits EGFR/MAPK/AP-1 and Activates TGF-β/Smad Signaling to Enhance Collagen Secretion and Reduce Photoaging

Cosmetics
Studies have consistently shown that long-wave ultraviolet A (UVA) radiation triggers skin photoaging, which is evident as reduced elasticity, a loss of firmness, and signs of aging.
Fan Daidi, Zhiguang Duan
exaly   +3 more sources

Pterostilbene and Its Glucoside Induce Type XVII Collagen Expression [PDF]

Natural Product Communications, 2017
The glycosylation of pterostilbene by cultured plant cells of Phytolacca americana gave pterostilbene 4′- O -β-D-glucoside. Both pterostilbene and its 4- O -β-D-glucoside induced type XVII collagen expression in the EpiDermFT EFT-400 human skin cell ...
Hiroki Hamada, Kei Shimoda, Yoshiyuki Horio, Tsubasa Ono, Ryusuke Hosoda, Noriyuki Nakayama, Koichi Urano   +6 more
doaj   +3 more sources

Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis [PDF]

Frontiers in Nutrition
BackgroundSkin aging involves intrinsic chronological aging and extrinsic photoaging, characterized by impaired barrier function, extracellular matrix (ECM) degradation, and chronic inflammation.MethodsThis study evaluated anti-aging efficacy and ...
Zhiqing Zhou, Zhiqing Zhou, Lingling Zhao, Lei Chen, Xuanxiang Zhao, Xinwei Li, Xuying Luo, Bin Zhang, Jianyin Miao, Feitong Liu, Feitong Liu   +10 more
doaj   +2 more sources

Physicochemical characterization, cellular bioactivity, and biosafety evaluation of type A recombinant humanized collagen type XVII

Journal of Applied Biomaterials and Functional Materials
Collagen type XVII is a unique transmembrane protein that plays a crucial role in anchoring epithelial cells to the underlying basement membrane. However, the low natural abundance of collagen type XVII in the human body poses significant challenges for ...
Nana Han
exaly   +2 more sources

BP180/Collagen XVII: A Molecular View. [PDF]

Int J Mol Sci, 2021
BP180 is a type II collagenous transmembrane protein and is best known as the major autoantigen in the blistering skin disease bullous pemphigoid (BP). The BP180 trimer is a central component in type I hemidesmosomes (HD), which cause the adhesion between epidermal keratinocytes and the basal lamina, but BP180 is also expressed in several non-HD ...
Tuusa J, Kokkonen N, Tasanen K.
europepmc   +5 more sources

Camellia sinensis Seed Flavonoids Attenuate UVB-Induced Inflammation and UVA-Induced Photodamage via MAPK/NF-κB and AP-1 Pathways [PDF]

Molecules
This study evaluated the anti-inflammation and anti-photoaging effects of Camellia sinensis seed flavonoids (CSF) against UVB and UVA irradiation and elucidated the underlying mechanisms.
Xiao-Xiao Duo, Ru-Biao Hou, Yuan-Cheng Huang, Lei Li, Jian-Ming Deng, Min Yu, Guang-Li Wang, Jing Wang   +7 more
doaj   +2 more sources

Identification of a human type XVII collagen fragment with high capacity for maintaining skin health

Synthetic and Systems Biotechnology
Collagen XVII (COL17) is a transmembrane protein that mediates skin homeostasis. Due to expression of full length collagen was hard to achieve in microorganisms, arising the needs for selection of collagen fragments with desired functions for microbial ...
Zhou Jw, Kangjie Xu, Ruiyan Wang
exaly   +3 more sources