Collagen XVII: A Shared Antigen in Neurodermatological Interactions? [PDF]
Clinical and Developmental Immunology, 2013 Collagen XVII is a nonfibril-forming transmembrane collagen, which functions as both a matrix protein and a cell-surface receptor. It is particularly copious in the skin, where it is known to be a structural component of hemidesmosomes.
Allan Seppänen
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The Role of Collagen XVII in Cancer: Squamous Cell Carcinoma and Beyond [PDF]
Frontiers in Oncology, 2020 Alterations in the extracellular matrix (ECM) likely facilitate the first steps of cancer cell metastasis and supports tumor progression. Recent data has demonstrated that alterations in collagen XVII (BP180), a transmembrane protein and structural ...
V A Jones, Payal M Patel, Kyle Amber
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Collagen XVII Processing and Blistering Skin Diseases [PDF]
Acta Dermato-Venereologica, 2020 Collagen XVII (COL17) is a hemidesmosomal transmembrane protein in the skin, which, in several autoimmune blistering skin diseases, may be targeted by autoantibodies.
Wataru Nishie
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PKM2-mediated collagen XVII expression is critical for wound repair [PDF]
JCI InsightChronic wounds have emerged as a tough clinical challenge. An improved understanding of wound-healing mechanisms is paramount. Collagen XVII (COL17), a pivotal constituent of hemidesmosomes, holds considerable promise for regulating epidermal cell ...
Yangdan Liu +7 more
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Involvement of collagen XVII in pluripotency gene expression and metabolic reprogramming of lung cancer stem cells [PDF]
Journal of Biomedical Science, 2020 Background Recent advancements in cancer biology field suggest that glucose metabolism is a potential target for cancer treatment. However, little if anything is known about the metabolic profile of cancer stem cells (CSCs) and the related underlying ...
Han-Shui Hsu +6 more
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G protein-coupled estrogen receptor 1 and collagen XVII endodomain expression in human cutaneous melanomas: can they serve as prognostic factors? [PDF]
Pathology and Oncology ResearchMelanoma incidence is increasing globally. Although novel therapies have improved the survival of primary melanoma patients over the past decade, the overall survival rate for metastatic melanoma remains low. In addition to traditional prognostic factors
Uğur Çakır +9 more
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Autoimmunity to Collagen XVII (BP180-Ag2) in Pemphigoid Associated With Parkinson’s Disease [PDF]
Case Reports in Dermatological MedicineThe association between Parkinson’s disease and autoimmune disease is rare; in our population, there is 1 case per 10,000 inhabitants. Bullous pemphigoid has a much lower incidence, and consequently, the association of Parkinson’s disease and bullous ...
Ricardo Cid-Puente +5 more
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Anti-idiotypic Antibodies against BP-IgG Prevent Type XVII Collagen Depletion
Frontiers in Immunology, 2017 Bullous pemphigoid (BP) mainly targets type XVII collagen (COL17). Intravenous immunoglobulin (IVIg) is used to treat numerous autoimmune diseases, including BP. The major mechanism of action for IVIG is thought to be its immunomodulatory effect. However,
Hideyuki Ujiie +2 more
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Therapeutic potential of recombinant human collagen XVII in blue light-induced skin photoaging: preserving epidermal-dermal structural integrity and functional homeostasis [PDF]
Frontiers in Bioengineering and BiotechnologyBackgroundExcessive exposure to blue light (BL) contributes to skin photoaging by inducing oxidative stress, inflammation, extracellular matrix degradation, and disruption of epidermal-dermal integrity. Recombinant human type XVII collagen (rhCol17) is a
Xudong Wang +12 more
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Exploring the Active Constituents of Andrographis paniculata in Protecting the Skin Barrier and the Synergistic Effects with Collagen XVII [PDF]
AntioxidantsAndrographis paniculata is mainly used to treat skin inflammations, wounds, and infections. In this study, Andrographis Herba, the aerial part of the plant, was proven to increase the viability of UVB-damaged HaCat cells and reduce reactive oxygen ...
Heng Xu +6 more
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