Results 271 to 280 of about 300,263 (378)

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Tendon overuse models have different effects on tissue mechanical properties in ex vivo bovine tendons. [PDF]

J Electromyogr Kinesiol
Moore ZM, Wood G, Elliott J, Simon JC, Vidt ME.   +4 more
europepmc   +1 more source

Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells.

Journal of Clinical Investigation, 1986
J. Dayer, B. G. Rochemonteix, B. Burrus, S. Demczuk, C. Dinarello   +4 more
semanticscholar   +1 more source

Interaction between Triple-‐Helical Collagens and Human Collagenases

, 2010
Szymon W. Manka
openalex   +1 more source

KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression

Advanced Science, EarlyView.
Cholangiocarcinoma (CCA) driven by oncogenic KRAS depends on its continuous activation for tumor maintenance. Using a conditional KRAS model, the authors show that turning off KRAS triggers rapid tumor regression accompanied by immune cell infiltration and cytokine release. The findings uncover a KRAS–senescence–immune signaling axis and highlight KRAS
Youwei Qiao, Matthew F. Yee, Chaitanya N. Parikh, Boyang Ma, Yueying Cao, Yu‐Huan Shih, Joae Qiong Wu, Marcus Ruscetti, Shun‐Qing Liang, Wen Xue   +9 more
wiley   +1 more source

Isolation and characterization of epithelial cells and fibroblasts from the human penile urethra. [PDF]

Front Bioeng Biotechnol
Brownell D, Elia E, Pellerin FA, Chabaud S, Larochelle S, Moulin VJ, Laungani A, Bolduc S.   +7 more
europepmc   +1 more source

Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.

Proceedings of the National Academy of Sciences of the United States of America, 1989
C. He, S. Wilhelm, A. Pentland, B. Marmer, G. A. Grant, A. Eisen, G. Goldberg   +6 more
semanticscholar   +1 more source

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Iron Toxicity in Mice with Collagenase-Induced Intracerebral Hemorrhage

Journal of Cerebral Blood Flow and Metabolism, 2011
He Wu, Tao Wu, Xueying Xu, Jessica Wang, Jian Wang   +4 more
semanticscholar   +1 more source