Results 21 to 30 of about 300,263 (378)

Dissociation of solid tumor tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase-associated stress responses

Genome Biology, 2019
Single-cell RNA sequencing (scRNA-seq) is a powerful tool for studying complex biological systems, such as tumor heterogeneity and tissue microenvironments.
C. O’Flanagan, Kieran R. Campbell, Allen W. Zhang, Farhia Kabeer, J. Lim, Justina Biele, P. Eirew, D. Lai, A. McPherson, Esther Kong, Cherie Bates, K. Borkowski, M. Wiens, Brittany Hewitson, J. Hopkins, Jenifer Pham, Nicholas Ceglia, Richard A. Moore, A. Mungall, J. McAlpine, Sohrab P. Shah, Samuel Aparicio   +21 more
semanticscholar   +1 more source

Potential Anti-aging Components From Moringa oleifera Leaves Explored by Affinity Ultrafiltration With Multiple Drug Targets

Frontiers in Nutrition, 2022
Moringa oleifera (M. oleifera), widely used in tropical and subtropical regions, has been reported to possess good anti-aging benefits on skincare.
Yongbing Xu, Yongbing Xu, Yongbing Xu, Yongbing Xu, Guilin Chen, Guilin Chen, Guilin Chen, Guilin Chen, Mingquan Guo, Mingquan Guo, Mingquan Guo, Mingquan Guo   +11 more
doaj   +1 more source

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

Journal of Biological Chemistry, 1995
Matrix metalloproteases are secreted by mammalian cells as zymogens and, upon activation, initiate tissue remodeling by proteolytic degradation of collagens and proteoglycans.
A. Strongin, I. Collier, G. Bannikov, B. Marmer, G. A. Grant, G. Goldberg   +5 more
semanticscholar   +1 more source

The Critical Role of MMP13 in Regulating Tooth Development and Reactionary Dentinogenesis Repair Through the Wnt Signaling Pathway

Frontiers in Cell and Developmental Biology, 2022
Matrix-metalloproteinase-13 (MMP13) is important for bone formation and remodeling; however, its role in tooth development remains unknown. To investigate this, MMP13-knockout (Mmp13−/−) mice were used to analyze phenotypic changes in the dentin–pulp ...
Henry F. Duncan, Yoshifumi Kobayashi, Yukako Yamauchi, Angela Quispe-Salcedo, Zhi Chao Feng, Jia Huang, Nicola C. Partridge, Teruyo Nakatani, Jeanine D’Armiento, Emi Shimizu   +9 more
doaj   +1 more source

Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice [PDF]

, 2013
Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH).
Arai, Ken, Cianchetti, Flor A., Fan, Xiang, Förch, Christian, Lauer, Arne, Leyen, Klaus van, Lo, Eng H., Mandeville, Emiri, Rosidi, Nathanael L., Schaffer, Chris B., Schlunk, Frieder, Steinmetz, Helmuth, Wang, Xiaoying, Yigitkanli, Kazim   +13 more
core   +3 more sources

Collagenase does Not Persist in Human Islets following Isolation

Cell Transplantation, 2012
Optimal human islet isolation requires the delivery of bacterial collagenase to the pancreatic islet–exocrine interface. However, we have previously demonstrated the presence of collagenase within human islets immediately following intraductal ...
Sarah E. Cross, Stephen J. Hughes, Anne Clark, Derek W. R. Gray, Paul R. V. Johnson   +4 more
doaj   +1 more source

Effects of Annona muricata Extract on Trypsin, Cathepsin B and Collagenase Activities and Textural Changes in Chilled Macrobrachium rosenbergii

Foods, 2023
Texture is an important sensory attribute for overall quality and consumer acceptance of prawns. However, texture is affected during cold storage due to the proteolytic activity of endogenous proteases, resulting in poor quality and a short shelf life ...
Amalina Ibrahim, Kamariah Bakar, Jamilah Bakar, Nilesh Prakash Nirmal, Mhd Ikhwanuddin, Nurul Ulfah Karim   +5 more
doaj   +1 more source

Ubiquitin-like protein from human placental extract exhibits collagenase activity.

PLoS ONE, 2013
An aqueous extract of human placenta exhibits strong gelatinase/collagenase activity in zymography. 2-D gel electrophoresis of the extract with gelatin zymography in the second dimension displayed a single spot, identified as ubiquitin-like component ...
Debashree De, Piyali Datta Chakraborty, Jyotirmoy Mitra, Kanika Sharma, Somnath Mandal, Aneesha Das, Saikat Chakrabarti, Debasish Bhattacharyya   +7 more
doaj   +1 more source

A mini review on the associations of matrix metalloproteinases (MMPs) -1, -8, -13 with periodontal disease

AIMS Molecular Science, 2021
Matrix metalloproteinases (MMPs) are one of the most important endopeptidases in periodontal disease that generally degrade extracellular matrix (ECM) components of periodontal supporting tissues, leading to tooth loss.
Fazle Khuda, Nur Najmi Mohamad Anuar , Badiah Baharin, Nurrul Shaqinah Nasruddin   +3 more
doaj   +1 more source

Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix [PDF]

, 2015
Despite the crucial role of extracellular matrix (ECM) in directing cell fate in healthy and diseased tissues--particularly in development, wound healing, tissue regeneration and cancer--the mechanisms that direct the assembly and regulate hierarchical ...
Gourdon, Delphine, Klotzsch, Enrico, Kubow, Kristopher E., Luna, Sheila, Smith, Michael L., Vogel, Viola, Vukmirovic, Radmila, Zhe, Lin   +7 more
core   +2 more sources