Results 51 to 60 of about 1,679,257 (316)
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
, 2003 This paper considers the phenomenon of deep core collapse in collisional stellar systems, with stars of equal mass. The collapse takes place on some multiple, $\xi ^{-1}$, of the central relaxation time, and produces a density profile in which $\rho ...
Aarseth +25 more
core +2 more sources
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Knots in Collapsible and Non-Collapsible Balls [PDF]
The Electronic Journal of Combinatorics, 2013 We construct the first explicit example of a simplicial 3-ball $B_{15,66}$ that is not collapsible. It has only 15 vertices. We exhibit a second 3-ball $B_{12,38}$ with 12 vertices that is collapsible and not shellable, but evasive. Finally, we present the first explicit triangulation of a 3-sphere $S_{18, 125}$ (with only 18 vertices) that is not ...
Benedetti, Bruno, Lutz, Frank H.
openaire +3 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Research on Structural Collapse of a Containership under Combined Bending–Torsion by Oblique Waves
Journal of Marine Science and EngineeringLarge waves cause a great number of collapsed-ship accidents, resulting in the loss of many lives and properties. It has been found that most of these collapses are caused by encountering oblique waves.
Weiqin Liu +4 more
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama +7 more
wiley +1 more source
A study of the risk ranking method of landslides and collapses
Shuiwen dizhi gongcheng dizhi, 2021 Geological disasters in China are characterized by multi-point and wide-range distribution, while the manpower and ability of geological disaster risk management and control are relatively limited.
Mingli XIE +5 more
doaj +1 more source
Inelastic Collapse of Three Particles
, 1996 A system of three particles undergoing inelastic collisions in arbitrary spatial dimensions is studied with the aim of establishing the domain of ``inelastic collapse''---an infinite number of collisions which take place in a finite time.
B. Bernu +11 more
core +1 more source