Results 41 to 50 of about 9,026,275 (240)
Dhaka University Journal of Pharmaceutical Sciences, 2023 Ulcerative colitis is a chronic inflammatory disease, and patients would get benefit more if the drug is given directly to the colon. Mesalazine is intended to deliver to the colon for treating ulcerative colitis. Here, we aimed to design and optimize mesalazine 400 mg delayed release tablet for colon-specific delivery using a quality by design (QbD ...
Diponkor Kumar Shill +4 more
openaire +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Starch film-coated microparticles for oral colon-specific drug delivery [PDF]
, 2018 The aim of this study was to prepare and characterize a novel type of starch-coated microparticles (MPs) allowing site-specific delivery of bioactives to the colon.
Jin Chen +7 more
core +1 more source
BioengineeringTo overcome the limitations of conventional therapies, targeted delivery of therapeutic interventions is crucial. Specifically, novel hydrogels maximize efficacy while minimizing the premature degradation of therapeutic enzymes.
Shagufta Kamal +6 more
doaj +1 more source
Levan in the developing of new colon-specific polymer material: evaluation of the permeability, moisture and thermal analyses in free films of Eudragit® FS 30 D = Levana no desenvolvimento de novo material polimérico cólon-específico: avaliação da permeabilidade, intumescimento e análises térmicas de filmes isolados de Eudragit® FS 30 D [PDF]
Acta Scientiarum. Health Sciences, 2012 Levan was used as agent in the synthesis of new colon-specific polymeric matrix together with Eudragit® FS 30 D. Eudragit® FS 30 D films incorporated with levan were made by casting process and characterized to: water vapour transmission, sweeling index,
Osvaldo Albuquerque Cavalcanti +4 more
doaj
Design and in vitro evaluation of formulations with pH and transit time controlled sigmoidal release profile for colon-specific delivery [PDF]
Drug Delivery, 2009 The primary objective of the study was to develop a pH and transit time controlled sigmoidal release polymeric matrix for colon-specific delivery of indomethacin. Tablet matrices were prepared using a combination of hydrophilic polymers (polycarbophil or carbopol) having pH sensitive swelling properties with hydrophobic polymer ethyl cellulose.
Laila Fatima, Ali Asghar +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Drug Design, Development and Therapy, 2017 Wooseong Kim, Yejin Yang, Dohoon Kim, Seongkeun Jeong, Jin-Wook Yoo, Jeong-Hyun Yoon, Yunjin Jung Laboratory of Biomedicinal Chemistry, Department of Manufacturing Pharmacy, College of Pharmacy, Pusan National University, Busan, Republic of Korea ...
Kim W +6 more
doaj
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Chinese Herbal Medicines, 2016 Abstract Objective To deliver multiple component drugs to colon site and sustain a synchronous release for better therapeutic effect. For achieving this purpose, colon specific pellet containing total alkaloids of Sophora alopecuroides (TASA) was prepared.
Li-ping Liang +5 more
openaire +1 more source