Results 51 to 60 of about 9,026,275 (240)

Microparticles as controlled drug delivery carrier for the treatment of ulcerative colitis: A brief review

Saudi Pharmaceutical Journal, 2014
Ulcerative colitis is the chronic relapsing multifactorial gastrointestinal inflammatory bowel disease, which is characterized by bloody or mucus diarrhea, tenesmus, bowel dystension, anemia.
Nidhi, Muzamil Rashid, Veerpal Kaur, Supandeep Singh Hallan, Saurabh Sharma, Neeraj Mishra   +5 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Current Update of Clinical Therapeutic Strategies for Colon-Targeted Delivery Systems

Pharmaceutical Sciences and Research
Oral colon-targeted drug delivery systems represent a significant advancement offering both systemic and local therapeutic effects for a range of intestinal diseases, including irritable bowel syndrome, inflammatory bowel disease, colonic bacterial ...
Risa Widiani Batubara, Fadlina Chany Saputri, Raditya Iswandana   +2 more
doaj   +1 more source

Orally delivered polycurcumin responsive to bacterial reduction for targeted therapy of inflammatory bowel disease

Drug Delivery, 2017
Inflammatory bowel disease (IBD) such as Crohn’s disease and ulcerative colitis is a chronic autoimmune disease affecting nearly five million people worldwide.
Hongzhi Qiao, Dong Fang, Jing Chen, Yuan Sun, Chen Kang, Liuqing Di, Junsong Li, Zhipeng Chen, Jun Chen, Yahan Gao   +9 more
doaj   +1 more source

Preparation of a colon-specific sustained-release capsule with curcumin-loaded SMEDDS alginate beads

RSC Advances, 2017
A colon-specific capsule with alginate beads containing a self-microemulsifying drug delivery system (SMEDDS) was developed and evaluated.
Yuxia Zhang, Yan Bai, Huali Chen, Yuanrui Huang, Pei Yuan, Liangke Zhang   +5 more
openaire   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Investigation into drug release from colon-specific azoreductase-activated steroid prodrugs using in-vitro models

Journal of Pharmacy and Pharmacology, 2011
Abstract Objectives The aim of this study was to investigate drug release from a double steroid prodrug, OPN501, which incorporates a phenylpropionate linker, and its phenylacetate analogue. The prodrugs, which were designed to deliver prednisolone to the colon for the treatment of inflammatory bowel ...
Juan F Marquez, Ruiz, Kinga, Kedziora, Henry, Windle, Dermot P, Kelleher, John F, Gilmer   +4 more
openaire   +2 more sources

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Degradation studies of modified inulin as potential encapsulation material for colon targeting and release of mesalamine

, 2022
S.102-108Due to the potential to treat colon specific diseases with reduced side effects, colon targeting has become of high interest over the last decades.
Walz, Michael, Trentzsch, Marcus, Henle, Thomas, Hagemann, Diana, Weber, Achim   +4 more
core   +1 more source

Development of a chitosan based double layer-coated tablet as a platform for colon-specific drug delivery

Drug Design, Development and Therapy, 2016
Min Soo Kim,1,* Dong Woo Yeom,1,* Sung Rae Kim,1 Ho Yub Yoon,1 Chang Hyun Kim,1 Ho Yong Son,1 Jin Han Kim,1 Sangkil Lee,2 Young Wook Choi1 1College of Pharmacy, Chung-Ang University, Seoul, 2College of Pharmacy, Keimyung University, Daegu, South Korea *
Kim MS, Yeom DW, Kim SR, Yoon HY, Kim CH, Son HY, Kim JH, Lee S, Choi YW   +8 more
doaj