Results 71 to 80 of about 9,026,275 (240)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

β-cyclodextrin-based multifunctional carriers for colon-targeted drug delivery: advances in hydrogel systems and mucoadhesive strategies

Cancer Nanotechnology
Oral drug delivery to the colon remains a formidable challenge due to the harsh conditions of the upper gastrointestinal tract, including variable pH, enzymatic degradation, and limited mucosal permeability.
Mousmee Sharma, Parteek Prasher, Rabab Fatima, Daniela Calina, Javad Sharifi-Rad   +4 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Colon constipation in horses after sustained-release buprenorphine administration. [PDF]

, 2018
OBJECTIVE To investigate the pharmacological profile and side effects of buprenorphine administered as a sustained-release formulation in horses. STUDY DESIGN Pilot trial.
Spadavecchia, Claudia, Graubner, Claudia, Levionnois, Olivier, Levionnois OL, Graubner C, Spadavecchia C   +5 more
core   +1 more source

A pH-sensitive silica nanoparticles for colon-specific delivery and controlled release of catechin: Optimization of loading efficiency and in vitro release kinetics

European Journal of Pharmaceutical Sciences
Catechin is a naturally occurring flavonoid of the flavan-3-ol subclass with numerous biological functions; however, these benefits are diminished due to several factors, including low water solubility and degradation in the stomach's harsh environment.
Abdulsalam M. Kassem, May Almukainzi, Tarek M. Faris, Ahmed H. Ibrahim, Walid Anwar, Ibrahim A. Elbahwy, Farid R. El-Gamal, Mohamed F. Zidan, Mohamed A. Akl, Ahmed M. Abd-ElGawad, Abdelsamed I. Elshamy, Mohammed Elmowafy   +11 more
openaire   +2 more sources

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Dextran and its potential use as tablet excipient [PDF]

, 2015
Dextrans are a class of carbohydrate polymers extensively applied in pharmaceutical applications, particularly as drug conjugate macromolecular carriers or drug delivery systems.
D. R. Perinelli, G. Bonacucina, G. F. Palmieri, Bonacucina, Giulia, Palmieri, Giovanni Filippo, Casettari, Luca, P. Lucaioli, PERINELLI, DIEGO ROMANO, Cespi, Marco, L. Casettari, Perinelli, Diego R., G. A. Morris, Morris, Gordon A., Lucaioli, Paolo, M. Cespi, Morris, Gordon A.; id_orcid   +15 more
core   +1 more source

Oral dosage forms for drug delivery to the colon: an existing gap between research and commercial applications

Journal of Materials Science: Materials in Medicine
Oral drug administration is the preferred route for pharmaceuticals, accounting for ~90% of the global pharmaceutical market due to its convenience and cost-effectiveness.
Estefanía Martínez, Jennifer Gamboa, Carla V. Finkielstein, Ana Isabel Cañas, Marlon Andrés Osorio, Yesid Vélez, Néstor Llinas, Cristina Isabel Castro   +7 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Synthesis, in-vitro characterization and pharmacological evaluation of conjugates of flurbiprofen and polysaccharides for colon specific drug delivery [PDF]

, 2019
The aim of the study was to prepare site specific drug delivery of flurbiprofen using polysaccharides by the formation of glycosidic linkage which is hydrolysed by the microflora present in colon.
Soni, P, Soni, K, Choudhary, GP
core   +1 more source