Results 101 to 110 of about 1,218,134 (318)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Long-term outcomes and lymph node metastasis following endoscopic resection with additional surgery or primary surgery for T1 colorectal cancer

Scientific Reports
Optimal management of T1 colorectal cancer (CRC) remains controversial. This study compared the long-term outcomes of endoscopic resection with additional surgical resection (ER + ASR) versus primary surgical resection (PS) in patients with T1 CRC and ...
Pin-Chun Chen, Yi-Kai Kao, Po-Wen Yang, Chia-Hung Chen, Chih-I Chen   +4 more
doaj   +1 more source

Native Cyclodextrin-Based Metal–Organic Frameworks (MOFs): Synthesis, Characterization, and Potential Applications in Food Industry

Molecules
Metal–organic frameworks (MOFs) have become a highly usable system in various sectors because of their highly ordered structure and high porosity providing them with high storage capacity.
Siddanth Saxena, Manuel J. Lis
doaj   +1 more source

Proteogenomic characterization of human colon and rectal cancer

Nature, 2014
Extensive genomic characterization of human cancers presents the problem of inference from genomic abnormalities to cancer phenotypes. To address this problem, we analysed proteomes of colon and rectal tumours characterized previously by The Cancer ...
Bing Zhang, Jing Wang, Xiaojing Wang, Jing Zhu, Qi Liu, Zhiao Shi, Matthew Chambers, L. Zimmerman, Kent Shaddox, Sangtae Kim, S. Davies, Sean Wang, Pei Wang, C. Kinsinger, Robert C. Rivers, H. Rodriguez, R. Townsend, Matthew J. C. Ellis, Steven A. Carr, David L. Tabb, R. Coffey, R. Slebos, Daniel C. Liebler, Steven A. Michael A. Karl R. Eric D. R. Philipp Karen A. Carr Gillette Klauser Kuhn Mani Mertins Ketchum Pa, Steve Carr, Michael A. Gillette, Karl R. Klauser, E. Kuhn, D. Mani, Philipp Mertins, K. Ketchum, A. Paulovich, Jeffrey R. Whiteaker, Nathan Edwards, P. McGarvey, Subha Madhavan, Pei Wang, Daniel W. Chan, A. Pandey, I. Shih, Hui Zhang, Zhen Zhang, Heng Zhu, Gordon A. Whiteley, S. Skates, F. White, D. Levine, Emily Boja, C. Kinsinger, Tara Hiltke, M. Mesri, Robert C. Rivers, H. Rodriguez, K. Shaw, S. Stein, David Fenyő, T. Liu, J. Mcdermott, S. Payne, K. Rodland, Richard D. Smith, P. Rudnick, Michael Snyder, Yingming Zhao, Xian Chen, D. Ransohoff, A. Hoofnagle, Daniel C. Liebler, M. Sanders, Zhiao Shi, R. Slebos, David L. Tabb, Bing Zhang, L. Zimmerman, Yue Wang, S. Davies, Li Ding, Matthew J. C. Ellis, R. Reid Townsend   +78 more
semanticscholar   +1 more source

Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize specific physiologic defects in anorectal dysfunction in systemic sclerosis (SSc) using anorectal manometry (ARM), evaluate associations with gastrointestinal (GI) and extraintestinal clinical phenotypes, and explore potential serologic markers for risk stratification.
Timothy Kaniecki, Alireza Amindarolzarbi, Tsion Abdi, John Clarke, Michael Hughes, Ami A. Shah, Zsuzsanna H. McMahan   +6 more
wiley   +1 more source

Local Pedicled Flaps and Biological Implant Options for Patients Undergoing Proctectomy for Crohn’s Disease When an Omental Pedicle Flap Is Not Possible

Medicina
Background and Objectives: Perineal wound complications and pelvic fluid collections or abscesses following proctectomy for Crohn’s disease are a common cause of morbidity and might be mitigated by filling the pelvis and occluding the pelvic inlet with a
Jacob Baxter, Ian S. Reynolds, Nho V. Tran, David W. Larson, Kellie L. Mathis, Nicholas P. McKenna   +5 more
doaj   +1 more source

Phase Field Failure Modeling: Brittle‐Ductile Dual‐Phase Microstructures under Compressive Loading

Advanced Engineering Materials, EarlyView.
The approach by Amor and the approach by Miehe and Zhang for asymmetric damage behavior in the phase field method for fracture are compared regarding their fitness for microcrack‐based failure modeling. The comparison is performed for the case of a dual‐phase microstructure with a brittle and a ductile constituent.
Jakob Huber, Jan Torgersen, Ewald Werner
wiley   +1 more source

Continuous Stiffness Graded Metal–Ceramic Femoral Stems: UMAT‐Based Design and Finite Element Assessment

Advanced Engineering Materials, EarlyView.
Functionally graded metal–ceramic femoral stems are engineered through continuous UMAT‐based stiffness tailoring, eliminating discrete material interfaces while enhancing biomechanical compatibility. Low‐index power‐law gradation optimizes load transfer, reduces stress shielding, and controls implant–bone micromotion, highlighting a materials‐design ...
Rihem Nouira, Sameh Elleuch, Hanen Jrad
wiley   +1 more source

Printed Integrated Logic Circuits Based on Chitosan‐Gated Organic Transistors for Future Edible Systems

Advanced Functional Materials, EarlyView.
Edible electronics needs integrated logic circuits for computation and control. This work presents a potentially edible printed chitosan‐gated transistor with a design optimized for integration in circuits. Its implementation in integrated logic gates and circuits operating at low voltage (0.7 V) is demonstrated, as well as the compatibility with an ...
Giulia Coco, Valerio Francesco Annese, Valerio Galli, Ilaria Penna, Debora Russo, Marina Veronesi, Rita Scarpelli, Stefania Sabella, Mario Caironi   +8 more
wiley   +1 more source