Results 221 to 230 of about 1,279,401 (299)

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Association of alcohol intake over the lifetime with colorectal adenoma and colorectal cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. [PDF]

Cancer
O'Connell CP, Berndt SI, Chudy-Onwugaje K, Kunzmann A, Huang WY, Barry KH, Loftfield E.   +6 more
europepmc   +1 more source

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

Nature Medicine, 2009
Shaoguang Wu, Ki-Jong Rhee, E. Albesiano, S. Rabizadeh, Xinqun Wu, Hung-Rong Yen, D. Huso, F. Brancati, E. Wick, F. McAllister, F. Housseau, D. Pardoll, C. Sears   +12 more
semanticscholar   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Case report: concurrent sigmoidectomy and schwannoma resection in a patient with recurrent diverticulitis. [PDF]

J Surg Case Rep
Dhanireddy KN, Dinapoli V, Kilaru S, Barrat C.   +3 more
europepmc   +1 more source

Molecular subtypes based on DNA methylation predict prognosis in colon adenocarcinoma patients

, 2019
Changshun Yang, Yu Zhang, Xiaoqin Xu, Weihua Li   +3 more
openalex   +2 more sources

KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression

Advanced Science, EarlyView.
Cholangiocarcinoma (CCA) driven by oncogenic KRAS depends on its continuous activation for tumor maintenance. Using a conditional KRAS model, the authors show that turning off KRAS triggers rapid tumor regression accompanied by immune cell infiltration and cytokine release. The findings uncover a KRAS–senescence–immune signaling axis and highlight KRAS
Youwei Qiao, Matthew F. Yee, Chaitanya N. Parikh, Boyang Ma, Yueying Cao, Yu‐Huan Shih, Joae Qiong Wu, Marcus Ruscetti, Shun‐Qing Liang, Wen Xue   +9 more
wiley   +1 more source

Itaconate-Related Gene Signatures as Prognostic Markers in Colon Cancer: Insights From Transcriptomic and Spatial Analysis. [PDF]

Hum Mutat
Zhang T, Meng J, Wang Q, Zhang P, Li H, Wei H, Chen D, Bai C, Nair S.   +8 more
europepmc   +1 more source

Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1

, 2012
Tae Il Kim
openalex   +2 more sources