Results 221 to 230 of about 1,581,828 (334)

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

Advanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis, Luis Carlos Sanjuan Acosta, Shubh P. Mehta, Baiyan Qi, Yang Yang, Luis Solorio, Craig J. Goergen, David J. Cappelleri   +7 more
wiley   +1 more source

α-Methyltryptophan mitigates cognitive impairment in db/db mice: involvement of gut-brain metabolic remodeling. [PDF]

Nutr Metab (Lond)
Cai A, Shen D, Xiong Q, Zhu Y, Di X, Yan Y, Chen Z, Yao Q, Chen R, Lin G, Kou L.   +10 more
europepmc   +1 more source

ST6GAL1‐Mediated Sialylation Stabilizes PD‐L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer

Advanced Science, EarlyView.
ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu, Jingyi Liu, Wei Qin, Chengsheng Ding, Zhenghao Cai, Duohuo Shu, Hao Zhong, Yanyan Hu, Mengqin Yu, Leqi Zhou, Jianwen Li, Minhua Zheng, Bin Li, Sen Zhang, Xiao Yang, Bo Feng   +15 more
wiley   +1 more source

Comparison of Tc-99 m scintigraphic method and radiological method for colon transmit assessment in patients with functional constipation. [PDF]

BMC Gastroenterol
Tian Y, Li Y, Yi T, Wang Q, Jiang X, He ZX.   +5 more
europepmc   +1 more source

FBXO44 Regulates FOXP1 Degradation Through AURKA‐Dependent Phosphorylation to Promote Colorectal Cancer Progression

Advanced Science, EarlyView.
FBXO44 promotes colorectal cancer progression by targeting FOXP1 for ubiquitin‐mediated degradation. This study reveals a phosphorylation‐dependent mechanism involving AURKA and highlights the FBXO44/FOXP1/Cyclin E2 axis as a potential therapeutic target in colorectal cancer.
Hongxu Nie, Hengjie Xu, Sheng Yang, Chuanxin Tian, Tuo Wang, Chi Jin, Zhihao Chen, Xiaowei Wang, Junwei Tang, Yifei Feng, Yueming Sun   +10 more
wiley   +1 more source

<b>Gut microbiota butyrate mediated RUNX3 promotes Nr4a1</b>^<b>high</b><b>ZFP36</b>^<b>high</b> <b>resident macrophages via NR4A1/ERK1/2 MAPK to maintain gut homeostasis</b>. [PDF]

Gut Microbes
Gao Y, Shi Y, Zhu N, Hao Y, Wang J, Zhang Y, Yang R.   +6 more
europepmc   +1 more source

SUPPRESSION OF SODIUM EXCRETION BY THE COLON IN CONGESTIVE HEART FAILURE AND CIRRHOSIS OF THE LIVER DEMONSTRATED BY THE USE OF CATION EXCHANGE RESINS 1 [PDF]

, 1952
Eugene Y. Berger, J. Murray Steele, Mary A. Homer, Gwendolyn P. Quinn   +3 more
openalex   +1 more source

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5

Advanced Science, EarlyView.
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao, Yuan Fei Li, Fu Kang Yuan, Meng Lu Zhao, Ya Wen Han, Jia Xin Wang, Qi Yang, Han Ying Ye, Yu Cheng Lu, Shao Chin Lee   +9 more
wiley   +1 more source

Smooth muscle cell (SMC)-Specific SNRK deletion in mouse causes congenital short bowel syndrome and premature death. [PDF]

Biochem Biophys Rep
Yu CJ, Ouyang L, An J, Ding Y, Liu ZX, Zhang ZR, Zou MH.   +6 more
europepmc   +1 more source

Extended Colotomy Incisions for Intraluminal Examination of the Colon

, 1956
Robert T. Gants, BRUCE A. RAYMOND, JAMES K. POPE   +2 more
openalex   +2 more sources