Results 51 to 60 of about 1,035,049 (315)

Colonic Protein Fermentation and Promotion of Colon Carcinogenesis by Thermolyzed Casein [PDF]

, 1995
Thermolyzed casein is known to promote the growth of aberrant crypt foci (ACF) and colon cancer when it is fed to rats that have been initiated with azoxymethane.
Thompson, Lilian, Bruce, W. Robert, Archer, Michael C., Rémésy, Christian, Medline, Alan, Corpet, Denis E.   +5 more
core  

Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: a prospective cohort study (The Netherlands). [PDF]

, 2005
OBJECTIVE: The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and rectal cancer.
Roemen, Guido M J M, Brandt, P.A. van den, Goldbohm, R.A., Goldbohm, R Alexandra, Lentjes, Marjolein H F M, Lentjes, Marjolein HFM, van den Brandt, Piet A, Wark, Petra A.; id_orcid, Goldbohm, R. Alexandra, Van Den Brandt, Piet A., Veer, P. van 't, van 't Veer, Pieter, Bruine, A.P., de, Weijenberg, Matty P., Weijenberg, Matty P, Roemen, G.M.J.M., de Bruïne, Adriaan P, de Goeij, Anton FPM, Wark, P.A., De Goeij, Anton F P M, Veer, P., van 't, Bruïne, A.P. de, Brink, M., van 't Veer, P., van den Brandt, P.A., Luchtenborg, M., Goeij, A.F.P.M. de, De Bruïne, Adriaan P., de Bruine, A.P., Weijenberg, M.P., Wark, Petra A, Lüchtenborg, Margreet, Roemen, Guido MJM, Brink, Mirian, de Goeij, A.F., Goeij, A.F.P.M., de, Lentjes, M.H.F.M., de Goeij, A.F.P.M., Van't Veer, Pieter, Brandt, P.A., van den   +39 more
core   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Immediate versus early (24-hours) urinary catheter removal after elective minimally invasive colonic resection: study protocol for a randomized, multicenter, non-inferiority trial

Trials, 2022
Background Enhanced Recovery After Surgery (ERAS) represents the standard of care in colorectal surgery. Among ERAS items, early removal of urinary catheter (UC) is considered a key issue, though adherence to this specific item still varies among centers.
Corrado Pedrazzani, Isacco Montroni, Cristian Conti, Giulia Turri, Caterina Foppa, Michele Carvello, Giovanni Taffurelli, Giampaolo Ugolini, Antonino Spinelli   +8 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

IL-1 in Colon Inflammation, Colon Carcinogenesis and Invasiveness of Colon Cancer [PDF]

Cancer Microenvironment, 2015
Interleukin-1 (IL-1) is a major "alarm" upstream pro-inflammatory cytokine that mainly acts by inducing cascades of cytokine and inflammation-promoting mediators. In the tumor arena, IL-1 is produced by both malignant and microenvironmental cells. IL-1α and IL-1β are the major agonists of IL-1, while IL-1Ra is a physiological inhibitor of pre-formed IL-
Elena, Voronov, Ron N, Apte
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Intermittent Chemoprevention of Colon Cancer

, 2015
This video shows the advantage of intermittent pulse schedules compared to constant schedules, for the chemoprevention of colon cancer in a computer simulation of cell dynamics in human colon crypts.Supplemental data for a manuscript prepared for ...
Axelrod, David E.
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Malakoplakia of the colon associated with colonic adenocarcinoma diagnosed in colonic biopsies

World Journal of Gastroenterology, 2007
Malakoplakia, typically involving the urinary tract, is an uncommon form of chronic inflammation caused by chronic infections and characterized by accumulation of macrophages. It has also been found in many other sites such as the gastrointestinal tract, pancreas, liver, lymph nodes, skin, respiratory tract, adrenal gland, vagina and brain.
F, Karasavvidou, S-P, Potamianos, S, Barbanis, E, Stathakis, A, Psychos, A-N, Kapsoritakis, G, Koukoulis   +6 more
openaire   +2 more sources