Results 61 to 70 of about 1,488,963 (303)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Citizen Journalist to Activist: the Language Behind Black Lives Matter [PDF]

, 2016
This study explores the discourse surrounding an event in the social movement, Black Lives Matter, to gain insights into how digital literacy practices influence and mediate participation in the 21st century civil rights movement for a new generation of ...
Colon, Valeriana
core   +1 more source

Sorting Nexin 1 Down-Regulation Promotes Colon Tumorigenesis [PDF]

, 2006
PURPOSE: Colon cancer is one of the most common human malignancies, yet studies have only begun to identify the multiple mechanisms that underlie the development of this tumor.
Bianchini, Michele, Campbell, Jean S., Furuya, Momoko H., Guncay, Gabriela D., Holdren, Matthew S., Levy, Estrella Mariel, Liu, Annie, Mordoh, Jose, Nguyen, Anthony P., Nguyen, Lananh N., Parks, W. Tony   +10 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Morphological Analyses of Colorectal Adenocarcinomas in Japanese Familial Adenomatous Polyposis Patients

Journal of the Anus, Rectum and Colon, 2022
Objectives: This retrospective study was conducted to clarify the morphological characteristics of colorectal cancer (CRC) in Japanese familial adenomatous polyposis (FAP) patients.
Yozo Suzuki, Fumio Ishida, Hideyuki Ishida, Hideki Ueno, Hirotoshi Kobayashi, Tatsuro Yamaguchi, Tsuyoshi Konishi, Yukihide Kanemitsu, Takao Hinoi, Yasuhiro Inoue, Naohiro Tomita, Kenichi Sugihara   +11 more
doaj   +1 more source

Breast, colon, and prostate screening in the adult population of Croatia: does rural origin matter? [PDF]

, 2007
INTRODUCTION: The aim of this study was to investigate the utilization of breast, colon and prostate cancer screening in the adult Croatian population in a period without national cancer screening programs, with a special interest in respondents' rural ...
Kern, Josipa, Kolčić, Ivana, Polašek, Ozren, Strnad, Marija, Vončina, Luka, Vuletić, Silvije   +5 more
core  

Clostridium septicum aortitis with synchronous ascending colon and rectal adenocarcinoma. [PDF]

, 2017
Clostridium septicum (C. septicum) aortitis is a rare condition frequently associated with colon adenocarcinoma and carries a poor prognosis. We report the case of a 66-year-old man who presented with abdominal pain, blood in the stool, fever and chills.
Jain, Deepanshu, Kistler, Andrew C., Kozuch, Patricia L.   +2 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Colon centreline calculation for CT colonography using optimised 3D opological thinning [PDF]

, 2002
CT colonography is an emerging technique for colorectal cancer screening. This technique facilitates noninvasive imaging of the colon interior by generating virtual reality models of the colon lumen.
Sadleir, Robert J.T., Whelan, Paul F.
core