Results 61 to 70 of about 1,052,853 (316)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Malakoplakia of the colon associated with colonic adenocarcinoma diagnosed in colonic biopsies

World Journal of Gastroenterology, 2007
Malakoplakia, typically involving the urinary tract, is an uncommon form of chronic inflammation caused by chronic infections and characterized by accumulation of macrophages. It has also been found in many other sites such as the gastrointestinal tract, pancreas, liver, lymph nodes, skin, respiratory tract, adrenal gland, vagina and brain.
F, Karasavvidou, S-P, Potamianos, S, Barbanis, E, Stathakis, A, Psychos, A-N, Kapsoritakis, G, Koukoulis   +6 more
openaire   +2 more sources

Colon Crypt Model 060518 C++

, 2018
C++ code ported from NetLogo code. Colon Crypt Model 110514 G.nlogo written in the application NetLogo. The NetLogo code and model are available at https://doi.org/doi:10.7282/T3KH0QKV.
Cockrell, Chase
core   +1 more source

Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: a prospective cohort study (The Netherlands). [PDF]

, 2005
OBJECTIVE: The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and rectal cancer.
Roemen, Guido M J M, Goldbohm, R.A., Goldbohm, R Alexandra, Lentjes, Marjolein H F M, Lentjes, Marjolein HFM, van den Brandt, Piet A, Wark, Petra A.; id_orcid, Goldbohm, R. Alexandra, Van Den Brandt, Piet A., van 't Veer, Pieter, Bruine, A.P., de, Weijenberg, Matty P., Weijenberg, Matty P, Roemen, G.M.J.M., de Bruïne, Adriaan P, de Goeij, Anton FPM, Wark, P.A., De Goeij, Anton F P M, Veer, P., van 't, Brink, M., van 't Veer, P., van den Brandt, P.A., Luchtenborg, M., De Bruïne, Adriaan P., de Bruine, A.P., Weijenberg, M.P., Wark, Petra A, Lüchtenborg, Margreet, Roemen, Guido MJM, Brink, Mirian, de Goeij, A.F., Goeij, A.F.P.M., de, Lentjes, M.H.F.M., Van't Veer, Pieter, Brandt, P.A., van den   +34 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Teatro Colon Program With 6 Signatures

, 1950
Teatro Colon Program With 6 ...
Teatro Colon Program
core   +1 more source

Co-occurrence and morphological analysis for colon tissue biopsy classification [PDF]

, 2006
Diagnosis and cure of colon cancer can be improved by efficiently classifying the colon tissue cells from biopsy slides into normal and malignant classes.
Rajpoot, Nasir M. (Nasir Mahmood), Qureshi, Hammad A., Rajpoot, Kashif, Masood, Khalid   +3 more
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Prognostic Value of Psoas Major Muscle Volume in Assessing Sarcopenia in Elderly Patients With Rectal Cancer

Annals of Gastroenterological Surgery
Background This study aimed to evaluate the clinical utility and prognostic significance of sarcopenia classification based on the psoas major muscle volume index (PVI) in elderly patients with rectal cancer.
Gen Tsujio, Shoichi Manabe, Akio Shiomi, Yusuke Tanaka, Shunsuke Kasai, Tadahiro Kojima, Takahiro Igaki, Yukihiro Mori, Akifumi Notsu   +8 more
doaj   +1 more source

Pharmacoeconomic analysis of adjuvant oral capecitabine vs intravenous 5-FU/LV in Dukes' C colon cancer: the X-ACT trial [PDF]

, 2006
Oral capecitabine (Xeloda^®) is an effective drug with favourable safety in adjuvant and metastatic colorectal cancer.
F Coxon, T S Maughan, Douillard, J.Y., Lesniewski-Kmak, K, Bertetto, O., Jelic, S., Maughan, T.S., Dufour, A., J-Y Douillard, Johnston, P G, C Twelves, Díaz-Rubio, E., Cassidy, J, Twelves, C., Jelic, S, P G Johnston, Figer, A, G Fountzilas, W Scheithauer, Patel, K K, Malzyner, A, Fountzilas, G., K Lesniewski-Kmak, A Malzyner, Bustová, I, Cowell, W., Garrison, L.P., Twelves, C, Díaz-Rubio, E, O Bertetto, W Cowell, Beham, A, S Jelic, Dufour, P, J J McKendrick, Scheithauer, W., Cowell, W, Lesniewski-Kmak, K., Garrison, L P, Bustová, I., Beham, A., Fountzilas, G, A Beham, K K Patel, I Bustová, Cassidy, J., McKendrick, J.J., Bertetto, O, L P Garrison, Coxon, F., Patel, K.K., Douillard, J-Y, P Dufour, A Figer, Johnston, P.G., Scheithauer, W, Coxon, F, Maughan, T S, J Cassidy, E Díaz-Rubio, McKendrick, J J, Malzyner, A., Figer, A.   +62 more
core   +1 more source