Results 81 to 90 of about 897,221 (299)

Serum extracellular vesicles contain SPARC and LRG1 as biomarkers of colon cancer and differ by tumour primary location [PDF]

, 2019
Min‐Er Zhong, Yanyu Chen, Yi Xiao, Lai Xu, Guannan Zhang, Junyang Lu, Huizhong Qiu, Wei Ge, Bin Wu   +8 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Local Pedicled Flaps and Biological Implant Options for Patients Undergoing Proctectomy for Crohn’s Disease When an Omental Pedicle Flap Is Not Possible

Medicina
Background and Objectives: Perineal wound complications and pelvic fluid collections or abscesses following proctectomy for Crohn’s disease are a common cause of morbidity and might be mitigated by filling the pelvis and occluding the pelvic inlet with a
Jacob Baxter, Ian S. Reynolds, Nho V. Tran, David W. Larson, Kellie L. Mathis, Nicholas P. McKenna   +5 more
doaj   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Identification, isolation and characterization of human LGR5-positive colon adenoma cells [PDF]

, 2018
Michael K. Dame, Durga Attili, Shannon D. McClintock, Priya H. Dedhia, Peter Ouillette, Olaf Hardt, Alana M. Chin, Xiang Xue, Julie Laliberté, Erica L. Katz, Gina M. Newsome, David R. Hill, Alyssa J. Miller, Yu-Hwai Tsai, David Agorku, Christopher Altheim, Andreas Bosio, B Simon, Linda C. Samuelson, Jay Stoerker, Henry D. Appelman, James Varani, Max S. Wicha, Dean E. Brenner, Yatrik M. Shah, Jason R. Spence, Justin A. Colacino   +26 more
openalex   +1 more source

Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4 [PDF]

, 2020
Sung Hee Choi, Emily C. Barker, Kyle J. Gerber, John J. Letterio, Byung‐Gyu Kim   +4 more
openalex   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

“Impact of regional data reporting and feedback on rectal cancer surgery quality metrics in the Surgical Care Outcomes Assessment Program (SCOAP)”

Surgery Open Science
Background: Management of rectal cancer is increasingly complex. Leading societies describe metrics of high-quality perioperative rectal cancer care with the goal of reducing variation in practice and improving outcomes.
Alex J. Charboneau, MD, MS, Chad Cragle, MD, PhD, Joseph Frankhouse, MD, Shalini Kanneganti, MD, Jenny A. Kaplan, MD, Ravi Moonka, MD, Laila Rashidi, MD, Vlad V. Simianu, MD, MPH   +7 more
doaj   +1 more source

Transition from Colitis to Cancer: High Wnt Activity Sustains the Tumor-Initiating Potential of Colon Cancer Stem Cell Precursors [PDF]

, 2012
Anitha Shenoy, Robert C. Fisher, Elizabeth A. Butterworth, Liya Pi, Lung-Ji Chang, Henry D. Appelman, Myron Chang, Edward W. Scott, Emina H. Huang   +8 more
openalex   +1 more source