Results 81 to 90 of about 1,775,938 (384)

Proximal colon–derived O-glycosylated mucus encapsulates and modulates the microbiota

Science, 2020
So much more to mucus Mammals accommodate a dense community of metabolically active microorganisms in their gut. This is not a passive relationship, and host and microbe have antagonistic as well as mutualistic responses to each other.
Kirk Bergstrom, Kirk Bergstrom, Xindi Shan, D. Casero, Albert Batushansky, V. Lagishetty, Jonathan P. Jacobs, Christopher M Hoover, Y. Kondo, Bojing Shao, Liang Gao, W. Zandberg, Benjamin Noyovitz, J. M. Mcdaniel, Deanna L. Gibson, S. Pakpour, N. Kazemian, Samuel McGee, C. Houchen, C. Rao, Timothy M. Griffin, Timothy M. Griffin, J. Sonnenburg, R. McEver, R. McEver, J. Braun, Lijun Xia, Lijun Xia   +27 more
semanticscholar   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Oncologic outcomes of squamous cell carcinoma of the anal canal after chemoradiation therapy [PDF]

Korean Journal of Clinical Oncology, 2016
Purpose The aim of this study is to analyze the oncological outcomes of squamous cell carcinoma (SCC) of the anal canal after chemoradiation therapy (CRT) in a single institution.
Dae Ro Lim, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Nam Kyu Kim   +5 more
doaj   +1 more source

Solid waste management in Puerto Rico : an assessment of environmental impacts and benefits [PDF]

, 2011
Municipal solid waste (MSW) management has been a challenging issue throughout history. Waste management options have evolved, but they can present distinct environmental impacts, such as the emission of greenhouse gases (GHG).
Martinez-Colon, Jose F.
core  

A Multilayer Monte Carlo Model for the Investigation of Optical Path and Penetration Depth at Different Perfusion States of the Colon [PDF]

, 2019
There is a great interest in monitoring the oxygen supply delivered to the colon. Insufficient oxygen delivery may lead to hypoxia, sepsis, multiorgan dysfunction and death.
Chatterjee, S., Kyriacou, P. A., Patel, Z., Thaha, M. A.   +3 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Restrictions of Brownian motion [PDF]

, 2014
Let $\{ B(t) \colon 0\leq t\leq 1\}$ be a linear Brownian motion and let $\dim$ denote the Hausdorff dimension. Let $\alpha>\frac12$ and $1\leq \beta \leq 2$.
Balka, Richárd, Peres, Yuval
core   +3 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Immediate versus early (24-hours) urinary catheter removal after elective minimally invasive colonic resection: study protocol for a randomized, multicenter, non-inferiority trial

Trials, 2022
Background Enhanced Recovery After Surgery (ERAS) represents the standard of care in colorectal surgery. Among ERAS items, early removal of urinary catheter (UC) is considered a key issue, though adherence to this specific item still varies among centers.
Corrado Pedrazzani, Isacco Montroni, Cristian Conti, Giulia Turri, Caterina Foppa, Michele Carvello, Giovanni Taffurelli, Giampaolo Ugolini, Antonino Spinelli   +8 more
doaj   +1 more source

Multi-peak solutions for magnetic NLS equations without non--degeneracy conditions [PDF]

, 2007
In the work we consider the magnetic NLS equation (\frac{\hbar}{i} \nabla -A(x))^2 u + V(x)u - f(|u|^2)u = 0 \quad {in} \R^N where $N \geq 3$, $A \colon \R^N \to \R^N$ is a magnetic potential, possibly unbounded, $V \colon \R^N \to \R$ is a multi-well ...
Cingolani, Silvia, Jeanjean, Louis, Secchi, Simone   +2 more
core   +7 more sources