Results 1 to 10 of about 1,115,327 (236)
The Proinflammatory Role of Guanylate-Binding Protein 5 in Inflammatory Bowel Diseases
Frontiers in Microbiology, 2022 NLRP3 inflammasome is implicated in the pathogenesis of inflammatory bowel diseases (IBD). Since guanylate-binding protein 5 (GBP5) induces the NLRP3 inflammasome activity, we aim to investigate the potential role of GBP5 in IBD pathogenesis.
Yichen Li +9 more
doaj +2 more sources
PLoS ONE, 2019 Epidemiological studies revealed that antibiotics exposure increases a risk of inflammatory bowel diseases (IBD) development. It remained largely unknown how antibiotic-induced dysbiosis confers the risk for enhanced inflammatory response. The aim of the
Yuliia Holota +10 more
doaj +2 more sources
The Effectiveness of Transabdominal Ultrasonography in Managing Chronic Constipation in the Elderly, with a Focus on the Underlying Pathological Conditions. [PDF]
Diagnostics (Basel)Chronic constipation is more common in the elderly and associated with numerous diseases. For the diagnosis of chronic constipation in the elderly, it is essential to exclude constipation secondary to colorectal cancer or other causes.
Manabe N, Fujita M, Haruma K.
europepmc +2 more sources
The Interaction of Large Bowel Microflora with the Colonic Mucus Barrier
International Journal of Inflammation, 2010 The colonic mucus barrier is the first line of defence that the underlying mucosa has against the wide range of potentially damaging agents of microbial, endogenous, and dietary origin that occur within the colonic lumen.
Jeffrey P. Pearson, Iain A. Brownlee
doaj +2 more sources
Microbiota-derived short-chain fatty acids: Implications for cardiovascular and metabolic disease
Frontiers in Cardiovascular Medicine, 2022 Cardiovascular diseases (CVDs) have been on the rise around the globe in the past few decades despite the existing guidelines for prevention and treatment.
Yingdong Lu +6 more
doaj +2 more sources
Cell organisation in the colonic crypt: a theoretical comparison of the pedigree and niche concepts. [PDF]
PLoS ONE, 2013 The intestinal mucosa is a monolayer of rapidly self-renewing epithelial cells which is not only responsible for absorption of water and nutrients into the bloodstream but also acts as a protective barrier against harmful microbes entering the body.
Richard C van der Wath +3 more
doaj +2 more sources
IRRITABLE BOWEL SYNDROME MANAGEMENT: BUMPY ROAD FOR PHYSICIANS
Khyber Medical University Journal, 2023 Irritable bowel syndrome is a complex gastrointestinal disorder related to over activity of nerves supplying the gut. 1It has been matter of enormous concern for both the patients and treating physicians’ .The clinical course is diverse and takes ...
Jibran Umar Ayub Khan +2 more
doaj +1 more source
Applied Sciences, 2021 Many functional food ingredients improve intestinal barrier function through their colonic fermentation products short chain fatty acids (SCFAs). Effects of individual SCFAs have been well studied, but the effects of SCFA mixtures–colonic fermentation ...
Yuan Yue +6 more
doaj +1 more source
MRISCs protect colonic stem cells from inflammatory damage
Cell Regeneration, 2021 Increasing evidence suggest functional roles of subepithelial mesenchymal niche cells in maintaining intestinal stem cells and in modulating the pathogenesis of various intestinal diseases in mammals.
Guoli Zhu, Rongwen Xi
doaj +1 more source
Инфекция и иммунитет, 2021 Psoriasis is a multifactorial systemic immune-associated disease. It is assumed that colonic dysbiosis may contribute to its development. In this review we provide the data on colonic dysbiosis in induction and progression of psoriatic inflammation ...
A. A. Goncharov, O. V. Dolgikh
doaj +1 more source