Results 61 to 70 of about 9,867,423 (273)

Minimally Invasive Methods of Temporary Decompression of the Colon with Obturation Colonic Obstruction: a Literature Review

Неотложная медицинская помощь, 2019
Colorectal cancer is one of the most common oncological diseases. In 40–60% of cases, patients with colorectal cancer enter general surgical hospitals with complications.
D. I. Petrov, P. A. Yartsev, D. A. Blagovestnov, V. D. Levitsky, B. T. Tsuleiskiri, I. I. Kirsanov, M. M. Rogal   +6 more
doaj   +1 more source

P086 Sirtuin 7 inhibitor attenuates colonic mucosal immune activation in mice–potential therapeutic target in Inflammatory Bowel Disease [PDF]

, 2023
Seung Hyun Kim, Y.T. Jeen, H J Jeon, E S Kim, B Keum, Hoon Jae Chun   +5 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Comparison of the Effect of the Routine Bowel Preparation and Use of Oral Sodium Phosphate on Acceptance and Bowel Cleansing in Patients Undergoing Colonoscopy: A Randomize Clinical Trial

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2010
Background and Objectives: Treatment team perform a variety of practices in the fields of treatment and caring. The main domain of nursing practice is to prepare patients for diagnostic tests.
A Ghanbari, M Ebrahim Musavi, M Yusefi Mash’hur, T Khaleghdoost, Z Atrkar Roshan   +4 more
doaj  

Lower Neighborhood Socioeconomic Status Associated with Reduced Diversity of the Colonic Microbiota in Healthy Adults. [PDF]

PLoS ONE, 2016
In the United States, there are persistent and widening socioeconomic gaps in morbidity and mortality from chronic diseases. Although most disparities research focuses on person-level socioeconomic-status, mounting evidence suggest that chronic diseases ...
Gregory E Miller, Phillip A Engen, Patrick M Gillevet, Maliha Shaikh, Masoumeh Sikaroodi, Christopher B Forsyth, Ece Mutlu, Ali Keshavarzian   +7 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Colectomia laparoscópica: revisão retrospectiva de 120 casos

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Relatar nossa experiência em cirurgia laparoscópica de cólon e analisar os resultados comparando-os à literatura. MÉTODOS: Analisamos retrospectivamente entre novembro de 1995 e outubro de 2006, 120 pacientes submetidos à ressecções ...
Júlio Cezar Uili Coelho, Renato Valmassoni Pinho, Júlio Japiassú Marinho de Macedo, Paulo César Andriguetto, Antônio Carlos Ligocki Campos   +4 more
doaj   +1 more source

The Interaction of Large Bowel Microflora with the Colonic Mucus Barrier

International Journal of Inflammation, 2010
The colonic mucus barrier is the first line of defence that the underlying mucosa has against the wide range of potentially damaging agents of microbial, endogenous, and dietary origin that occur within the colonic lumen.
Jeffrey P. Pearson, Iain A. Brownlee
doaj   +1 more source

Frizzled are colonic epithelial receptors for Clostridium difficile toxin B

Nature, 2016
Clostridium difficile toxin B (TcdB) is a critical virulence factor that causes diseases associated with C. difficile infection. Here we carried out CRISPR–Cas9-mediated genome-wide screens and identified the members of the Wnt receptor frizzled family ...
Liang Tao, Jie Zhang, Paul Meraner, Alessio Tovaglieri, Xiaoqian Wu, R. Gerhard, Xinjun Zhang, W. Stallcup, Ji Miao, Xi He, J. Hurdle, D. Breault, A. Brass, M. Dong   +13 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source