Results 61 to 70 of about 940,174 (383)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

On the proper treatment of pathologies in biomedical ontologies [PDF]

, 2005
In previous work on biomedical ontologies we showed how the provision of formal definitions for relations such as is_a and part_of can support new types of auto-mated reasoning about biomedical phenomena.
Kumar, Anand, Smith, Barry
core  

Metallopanstimulin as a marker for head and neck cancer [PDF]

, 2004
BACKGROUND: Metallopanstimulin (MPS-1) is a ribosomal protein that is found in elevated amounts in the sera of patients with head and neck squamous cell carcinoma (HNSCC).
A Agrawal, A Dietz, BC Stack Jr, CS Hollenbeak, DJ Santa Cruz, DR Ganger, DR Ganger, E Tartour, H Kasai, H Naora, H Quon, IG Wool, IG Wool, JA Fernandez-Pol, JA Fernandez-Pol, JA Fernandez-Pol, JA Fernandez-Pol, JA Fernandez-Pol, JT Wadsworth, JT Wadsworth, M Schmidt, PA Rockledge, RR Million, TN Teknos, VJ Lowe, WJ Lee, Y Atsuta, YL Chan, YL Chan   +28 more
core   +4 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Adenocarcinoma Originating from a Mature Teratoma of the Testis

Kaohsiung Journal of Medical Sciences, 2007
Malignant transformation in testicular teratomas has been reported very rarely in the literature. Although testicular teratomas in childhood are regarded as benign neoplasms, these tumors, if left untreated until advanced ages, may present the risk of ...
Resit Dogan Koseoglu, Bekir Suha Parlaktas, Nurper Onuk Filiz, Fikret Erdemir, Nihat Uluocak, Ozden Tulunay   +5 more
doaj   +1 more source

Large cell neuroendocrine carcinoma in the unusual location of the descending colon

Radiology Case Reports, 2020
Neuroendocrine neoplasms are most often found in the small intestine, rectum, appendix, and stomach. The colon, excluding the appendix and the cecum, is a rare location for these neoplasms and often gives rise to highly proliferative, poorly ...
Jin-whan Cha, DO, Millet Yang, DO, Alan Mo, DO   +2 more
doaj   +1 more source

Fluorescence lifetime spectroscopy of tissue autofluorescence in normal and diseased colon measured ex vivo using a fiber-optic probe

, 2013
We present an ex vivo study of temporally and spectrally resolved autofluorescence in a total of 47 endoscopic excision biopsy/resection specimens from colon, using pulsed excitation laser sources operating at wavelengths of 375 nm and 435 nm.
Chorvat, Chwirot, Chwirot, Cothren, Cothren, Cross, Curvers, De Beule, Drezek, Duraipandian, Eker, Fang, Georgakoudi, Georgakoudi, Glanzmann, Gono, Hilska, Hotouras, Huang, Jo, Kapadia, Kara, Kiesslich, Lambert, Li, Lin, Lovat, Maarek, Manning, Marcu, Mayinger, Mayinger, Mayinger, McGinty, Mizeret, Mycek, Nakaniwa, Nakashima, Palero, Palmer, Pfefer, Pitts, Ramanujam, Rex, Richards-Kortum, Schomacker, Schomacker, Schweitzer, Shao, Shim, Skala, Taplin, Thompson, Vishwasrao, Vogelstein, Wagnières, Wallace, Wang, Williams, Xiao, Yang, Zhuo, Zhuo, Zhuo, Zhuo, Zonios   +65 more
core   +1 more source

Screening Relevance of Sessile Serrated Polyps [PDF]

, 2019
Conventional adenomas have historically been considered to be the only screening-relevant colorectal cancer (CRC) precursor lesion. The prevailing paradigm was that most CRCs arise along the chromosomal instability pathway, where adenomas accumulate ...
Kahi, Charles J.
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Lymphoma caused by intestinal microbiota. [PDF]

, 2014
The intestinal microbiota and gut immune system must constantly communicate to maintain a balance between tolerance and activation: on the one hand, our immune system should protect us from pathogenic microbes and on the other hand, most of the millions ...
Schiestl, Robert H, Yamamoto, Mitsuko L
core   +2 more sources