Results 91 to 100 of about 939 (180)
mBio, 2022 Enterohemorrhagic E. coli (EHEC) is a natural human pathogen that poorly colonizes mice. Hence, the use of murine models to understand features of EHEC infection is a challenge.
Fernando H. Martins +5 more
openaire +3 more sources
MYADM binds human parechovirus 1 and is essential for viral entry [PDF]
Human parechoviruses (PeV-A) are increasingly being recognized as a cause of infection in neonates and young infants, leading to a spectrum of clinical manifestations ranging from mild gastrointestinal and respiratory illnesses to severe sepsis and ...
Carette, Jan E +6 more
core +2 more sources
Intestinal organoids as new treatments for inflammatory bowel disease [PDF]
, 2020 Inflammatory bowel disease (IBD) causes inflammation in any part of gastrointestinal (GI) tract and the main reason for the occurrence of this disease is not still known.
Davoudi, Zahra
core +3 more sources
Molecular biosignatures and gut-barrier alterations in inflammatory bowel diseases [PDF]
, 2022 Inflammatory bowel diseases (IBD) are chronic immune-mediated disorders affecting the gastrointestinal tract. The multifactorial pathophysiology of IBD is commonly explained as an abnormal interplay between genetic, immune, environmental and microbial ...
Moraes Holst, Luiza
core +1 more source
Advanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden +5 more
wiley +1 more source
A59 GLOBAL PROTEOMIC PROFILING OF HUMAN COLONOID MONOLAYERS UNDERGOING IN VITRO CHRONIC DAMAGE
Journal of the Canadian Association of Gastroenterology, 2023 Abstract Background An in vitro damage model has been established in our lab using human colonoids grown as 2D monolayers. Upon being subjected to repeated rounds of air-liquid interface (ALI) growth and injury by submergence, these colonoid monolayers lost their barrier integrity and regrowth ...
Sandilya, S +3 more
openaire +1 more source
The Journal of Pathology, Volume 265, Issue 1, Page 26-40, January 2025.Abstract Patients with familial adenomatous polyposis (FAP) harbor mutations in the APC gene and will develop adenoma and early colorectal cancer. There is no validated treatment, and animal models are not sufficient to study FAP. Our aim was to investigate the early events associated with FAP using the intestinal organoid model in a single‐center ...
Nolwenn Laborde +19 more
wiley +1 more source
Calcium-Induced Differentiation in Normal Human Colonoid Cultures
, 2018 ABSTRACT Colonoid cultures were established from histologically-normal human colon tissue and maintained in a low-calcium (0.25 mM) medium or in medium supplemented with an amount of calcium (1.5 - 3.0 mM) that was shown in a previous study to induce differentiation in colonoids derived from large adenomas.
Attili, Durga +11 more
openaire +1 more source
Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform
Stem Cell Reports, 2017 Summary: We describe the development and characterization of a mouse and human epithelial cell monolayer platform of the small and large intestines, with a broad range of potential applications including the discovery and development of minimally ...
Kenji Kozuka +15 more
doaj +1 more source
The Role of Bacterial Proteases From the Microbiome in Human Disease
Cellular Microbiology, Volume 2025, Issue 1, 2025.Proteases degrade proteins and peptides, recycling materials and preventing unnecessary buildup within the cell. They can also be secreted and act in extracellular space. Bacterial proteases are often secreted and function as virulence factors. In the context of the microbiome, they can contribute to host–microbe interactions to facilitate colonization
Ying-Chiang J. Lee +1 more
wiley +1 more source