Results 101 to 110 of about 939 (180)
Optimization of 3-D organotypic primary colonic cultures for organ-on-chip applications [PDF]
, 2014 Background New advances enable long-term organotypic culture of colonic epithelial stem cells that develop into structures known as colonoids. Colonoids represent a primary tissue source acting as a potential starting material for development of an in ...
Ahmad, Asad A +5 more
core +2 more sources
Advanced Science, Volume 11, Issue 47, December 18, 2024.Xiaoheng Liu, Jing Xie and co‐workers dissect the novel role of OMVs derived from F. nucleatum in the occurrence of periodontitis. The severity of periodontitis caused by OMVs is close to the effect of F. nucleatum itself, due to the activations of NLRP3 inflammasomes, inflammatory factors, and extracellular degradation.
Li Zhang +16 more
wiley +1 more source
DEVELOPING HIGH THROUGHPUT ORGANOID-BASED PLATFORMS TO STUDY ENTERIC PHYSIOLOGY IN VITRO [PDF]
, 2018 The human gastrointestinal lumen is a complex environment where microbial resents (microbiota) interact symbiotically and pathogenically with the host intestinal mucosa. Intestinal health is regulated by these interactions as they relate to host genetics
Williamson, Ian
core +2 more sources
The expression of intestinal Cyp2c55 is regulated by the microbiota and inflammation
The FASEB Journal, Volume 38, Issue 20, 31 October 2024.Cyp2c55 is highly expressed in the colonic epithelial cells of mice in a microbiota‐dependent manner. The underlying mechanism seems to involve a BA‐mediated PXR activation. Furthermore, the colonic expression of Cyp2c55 is also subject to regulation by the inflammatory response. While the physiological function of Cyp2c55 remains largely unidentified,
Adrian Hilman +8 more
wiley +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2018 Background & Aims: Chronic inflammation is a predisposing condition for colorectal cancer. Many studies to date have focused on proinflammatory signaling pathways in the colon.
Anna L. Means +23 more
doaj +1 more source
Automation of Microraft Arrays for Stem Cell Analysis and Sorting [PDF]
, 2018 Induced pluripotent stem cells (iPSCs) are reprogrammed somatic cells with the potential to revolutionize personalized medicine, disease modeling, and tissue engineering.
DiSalvo, Matthew
core +2 more sources
Host–diet–microbiota interplay in intestinal nutrition and health
FEBS Letters, Volume 598, Issue 20, Page 2482-2517, October 2024.Quantitative or qualitative alterations in intestinal resident microbe composition can lead to microbiota imbalance, namely intestinal dysbiosis, in both flies and humans. Intestinal microbiota dysbiosis, in turn, deregulates host physiology and contributes to the development, as well as the severity, of various types of intestinal and other diseases ...
Anastasia Ignatiou, Chrysoula Pitsouli
wiley +1 more source
SARS-CoV-2 Omicron BA.1 variant infection of human colon epithelial cells [PDF]
The Omicron variant of SARS-CoV-2, characterized by multiple subvariants including BA.1, XBB.1.5, EG.5, and JN.1, became the predominant strain in early 2022.
Alvarado, David M +7 more
core +2 more sources
Microbial Biotechnology, Volume 17, Issue 10, October 2024.This review discusses novel strategies to specifically target and evaluate the mucosal microbiota, such as culturomics applied to mucosal biopsies, intestinal organoids and artificial in vitro models incorporating mucus. Abstract A healthy mucus is essential for maintaining intestinal homeostasis and overall well‐being.
Marco Calvigioni +4 more
wiley +1 more source
A Preclinical Model to Assess Intestinal Barrier Integrity Using Canine Enteroids and Colonoids
BiologyWhile two-dimensional (2D) cell cultures, such as Caco-2 and Madin–Darby canine kidney (MDCK) cells are widely used in a variety of biological models, these two-dimensional in vitro systems present inherent limitations in replicating the complexities of in vivo biology.
Megan P. Corbett +16 more
openaire +4 more sources