Results 111 to 120 of about 939 (180)
The FASEB Journal, Volume 38, Issue 16, 31 August 2024.Interferon‐gamma (IFNγ) exhibits a dual role in colonic tissue repair by promoting TNF‐alpha receptor 2 (TNFRSF1B) expression on intestinal epithelial cells (IEC) after injury. In vitro studies show IFNγ induces a STAT1‐dependent increase in TNFR2, while in vivo and in situ analyses reveal elevated Tnfrsf1b mRNA levels in colonic wounds.
Sean Watson +4 more
wiley +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2019 Background & Aims: SLC26A3 (DRA) is an electroneutral Cl-/HCO3- exchanger that is present in the apical domain of multiple intestinal segments. An area that has continued to be poorly understood is related to DRA regulation in acute adenosine 3′,5 ...
Chung-Ming Tse +7 more
doaj +1 more source
Derivation of adult canine intestinal organoids for translational research in gastroenterology
BMC Biology, 2019 Background Large animal models, such as the dog, are increasingly being used for studying diseases including gastrointestinal (GI) disorders. Dogs share similar environmental, genomic, anatomical, and intestinal physiologic features with humans.
Lawrance Chandra +20 more
doaj +1 more source
3D intestinal organoids in metabolic research:virtual reality in a dish [PDF]
, 2017 The advent of near physiological organoid technology has produced a step change in our understanding of stem cells and has provided the research community with a powerful new cell based tool to model human physiology and disease.
Bewick, Gavin A +2 more
core +2 more sources
Frontiers in Microbiology, 2019 Microbial metabolites, including B complex vitamins contribute to diverse aspects of human health. Folate, or vitamin B9, refers to a broad category of biomolecules that include pterin, para-aminobenzoic acid (pABA), and glutamate subunits.
Melinda A. Engevik +16 more
doaj +1 more source
Distinct Levels of Sox9 Expression Mark Colon Epithelial Stem Cells that Form Colonoids in Culture [PDF]
, 2011 Sox9 is an high-mobility group box transcription factor that is expressed in the stem cell zone of the small intestine and colon. We have previously used a Sox9EGFP mouse model to demonstrate that discrete levels of Sox9 expression mark small intestine ...
Daughtridge, G. W. +4 more
core +2 more sources
Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis [PDF]
, 2018 Neutrophil influx into the intestinal lumen is a critical response to infectious agents, but is also associated with severe intestinal damage observed in idiopathic inflammatory bowel disease. The chemoattractant hepoxilin A3, an eicosanoid secreted from
Demma, Zachary +12 more
core +2 more sources
Inflammatory Bowel Diseases, 2019 AbstractBackgroundAlterations to epithelial tight junctions can compromise the ability of the epithelium to act as a barrier between luminal contents and the underlying tissues, thereby increasing intestinal permeability, an early critical event in inflammatory bowel disease (IBD).
Sayoc-Becerra, Anica +8 more
openaire +5 more sources
Establishment of murine organoids with defined states of differentiation as a model for colonic ion transport [PDF]
, 2020 Hensel, Inga Viktoria
core +1 more source