Gastro Hep Advances, 2023 Background and Aims: A key histopathological feature of inflammatory bowel disease is damage to the mucosa, including breakdown of the epithelial barrier.
Tatiana A. Karakasheva +17 more
doaj +3 more sources
Epithelial WNT2B and Desert Hedgehog Are Necessary for Human Colonoid Regeneration after Bacterial Cytotoxin Injury [PDF]
iScience, 2020 Summary: Intestinal regeneration and crypt hyperplasia after radiation or pathogen injury relies on Wnt signaling to stimulate stem cell proliferation.
Julie G. In +10 more
doaj +3 more sources
Engineered extracellular vesicles reprogram T cells by targeting PD-1 and PHB1 signaling in inflammatory bowel disease [PDF]
Signal Transduction and Targeted TherapyCurrent therapies for inflammatory bowel disease (IBD) often fail to achieve complete remission and are associated with systemic toxicity owing to their broad immunosuppressive effects.
Mi-Kyung Oh +15 more
doaj +2 more sources
A High-Throughput Organoid Microinjection Platform to Study Gastrointestinal Microbiota and Luminal PhysiologySummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2018 Background & Aims: The human gut microbiota is becoming increasingly recognized as a key factor in homeostasis and disease. The lack of physiologically relevant in vitro models to investigate host–microbe interactions is considered a substantial ...
Ian A. Williamson +10 more
doaj +3 more sources
Measurement of Real-Time Serotonin Dynamics from Human-Derived Gut Organoids. [PDF]
Anal ChemThe importance of the gut in regulating the brain-body immune axis is becoming increasingly evident. Interestingly, the brain and gut share many common signaling molecules, with serotonin being one of the most notable.
Bohl B, Lei Y, Bewick GA, Hashemi P.
europepmc +3 more sources
Pathogenesis of adherent-invasive <i>Escherichia coli</i> LF82 in human colonic epithelium is characterized by adhesive biofilms, mucus penetration, and contact-dependent cytotoxicity. [PDF]
Gut MicrobesAdherent-invasive Escherichia coli (AIEC) associated with Crohn’s disease (CD) are traditionally defined by adherence and invasion of epithelial cells and survival in macrophages.
Evans BF +4 more
europepmc +3 more sources
High-fat diet enhances cell proliferation and compromises intestinal permeability in a translational canine intestinal organoid model [PDF]
BMC Molecular and Cell BiologyBackground Emerging evidence underscores the responsiveness of the mammalian intestine to dietary cues, notably through the involvement of LGR5 + intestinal stem cells in orchestrating responses to diet-driven signals.
Itsuma Nagao, Yoko M. Ambrosini
doaj +2 more sources
PLoS ONE, 2019 Background and aimsThe goal of the study was to assess calcium alone and Aquamin, a multi-mineral natural product that contains magnesium and detectable levels of 72 trace elements in addition to calcium, for capacity to affect growth and differentiation
Durga Attili +11 more
doaj +3 more sources
Capture and 3D culture of colonic crypts and colonoids in a microarray platform [PDF]
Lab on a Chip, 2013 Crypts are the basic structural and functional units of colonic epithelium and can be isolated from the colon and cultured in vitro into multi-cell spheroids termed “colonoids”.
Ahmad, Asad A. +5 more
core +5 more sources
The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response [PDF]
Journal of Translational MedicineBackground ERAP2 is an aminopeptidase involved in antigen processing and presentation, and harbor genetic variants linked to several inflammatory diseases such as Inflammatory Bowel Disease (IBD).
Siri Sæterstad +4 more
doaj +2 more sources