Results 41 to 50 of about 939 (180)
IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress [PDF]
, 2020 IRE1β is an ER stress sensor uniquely expressed in epithelial cells lining mucosal surfaces. Here, we show that intestinal epithelial cells expressing IRE1β have an attenuated unfolded protein response to ER stress.
Acosta-Alvear +54 more
core +1 more source
Drivers of Transcriptional Variance in Human Intestinal Epithelial Organoids [PDF]
, 2021 Human intestinal epithelial organoids (enteroids and colonoids) are tissue cultures used for understanding the physiology of the human intestinal epithelium.
Arimura, Sumimasa +28 more
core +2 more sources
Frontiers in Cell and Developmental Biology, 2020 Cell line authentication is critical for preventing the use of mixed or misidentified cell lines in research. Current efforts include short tandem repeat (STR) analysis and PCR-based assays to detect mixed species cultures.
Margaret S. Bohm +12 more
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2016 Background & Aims: Enterohemorrhagic Escherichia coli (EHEC) causes over 70,000 episodes of foodborne diarrhea annually in the United States. The early sequence of events that precede life-threatening hemorrhagic colitis and hemolytic uremic syndrome is ...
Julie In +10 more
doaj +1 more source
Single Cell Analysis of Human Colonoids Exposed to Uranium-Bearing Dust. [PDF]
Environ Health PerspectUranium exposure remains an important environmental legacy and physiological health concern, with hundreds of abandoned uranium mines located in the Southwestern United States largely impacting underserved indigenous communities. The negative effects of heavy metals on barrier permeability and inhibition of intestinal epithelial healing have been ...
Atanga R +7 more
europepmc +3 more sources
Fecal Luminal Factors from Patients with Gastrointestinal Diseases Alter Gene Expression Profiles in Caco-2 Cells and Colonoids [PDF]
, 2022 Previous in vitro studies have shown that the intestinal luminal content, including metabolites, possibly regulates epithelial layer responses to harmful stimuli and promotes disease.
6hman, Lena +9 more
core +2 more sources
Co‐Culture System of Human Enteroids/Colonoids with Innate Immune Cells
Current Protocols in Immunology, 2020 AbstractHuman intestinal enteroids derived from adult stem cells offer a relevant ex vivo system to study biological processes of the human gut. They recreate cellular and functional features of the intestinal epithelium of the small intestine (enteroids) or colon (colonoids) albeit limited by the lack of associated cell types that help maintain tissue
Janet F, Staab +4 more
openaire +3 more sources
PLoS ONE, 2020 Background and aimsHuman colonoid cultures maintained under low-calcium (0.25 mM) conditions undergo differentiation spontaneously and, concomitantly, express a high level of tight junction proteins, but not desmosomal proteins.
Shannon D McClintock +11 more
doaj +1 more source
Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coli. [PDF]
, 2016 Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens.
McCole, Declan F, Shawki, Ali
core +1 more source
Concise Review: The Potential Use of Intestinal Stem Cells to Treat Patients With Intestinal Failure. [PDF]
, 2016 : Intestinal failure is a rare life-threatening condition that results in the inability to maintain normal growth and hydration status by enteral nutrition alone.
Dunn, James CY +3 more
core +1 more source