Results 61 to 70 of about 939 (180)
Cellular and Molecular Gastroenterology and Hepatology, 2023 Background & Aims: The colonic epithelium requires continuous renewal by crypt resident intestinal stem cells (ISCs) and transit-amplifying (TA) cells to maintain barrier integrity, especially after inflammatory damage.
Ansen H.P. Burr +19 more
doaj +1 more source
Excess Dietary Sugar Alters Colonocyte Metabolism and Impairs the Proliferative Response to Damage [PDF]
, 2023 Background & Aims The colonic epithelium requires continuous renewal by crypt resident intestinal stem cells (ISCs) and transit-amplifying (TA) cells to maintain barrier integrity, especially after inflammatory damage.
Beyaz, Semir +19 more
core +1 more source
, 2023 SUMMARYChronic exposure to environmental toxins and heavy metals has been associated with intestinal inflammation, increased susceptibility to pathogen-induced diseases, and higher incidences of colorectal cancer, all of which have been steadily increasing in prevalence for the past 40 years. The negative effects of heavy metals on barrier permeability
Roger Atanga +6 more
openaire +2 more sources
Human Colonoid Monolayers to Study Interactions Between Pathogens, Commensals, and Host Intestinal Epithelium [PDF]
Journal of Visualized Experiments, 2019 Human 3-dimensional (3D) enteroid or colonoid cultures derived from crypt base stem cells are currently the most advanced ex vivo model of the intestinal epithelium. Due to their closed structures and significant supporting extracellular matrix, 3D cultures are not ideal for host-pathogen studies.
In, Julie G. +3 more
openaire +2 more sources
Working with patient-derived enteroids and colonoids v1
, 2023 This is a compilations of working with patient-derived enteroids or colonoids, from recovery to cryopreservation, in expansion culture (minimal differentiation)
openaire +1 more source
Chromatin Laser Imaging Reveals Abnormal Nuclear Changes for Early Cancer Detection
, 2018 We developed and applied rapid scanning laser-emission microscopy to detect abnormal changes in cell nuclei for early diagnosis of cancer and cancer precursors.
Aslam, Muhammad Nadeem +6 more
core +1 more source
Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium [PDF]
, 2022 Major Histocompatibility Complex (MHC)-I and -II genes are upregulated in intestinal epithelial cells (IECs) during active inflammatory bowel diseases (IBD), but little is known about how IBD-relevant pro-inflammatory signals and IBD drugs can regulate ...
Bakke, Ingunn +8 more
core +1 more source
Working with patient-derived enteroids and colonoids v2
, 2023 This is a compilations of protocols for working with patient-derived enteroids or colonoids, from recovery to cryopreservation, in expansion culture (minimal differentiation)
openaire +1 more source
Development of Arrayed Colonic Organoids for Screening of Secretagogues Associated with Enterotoxins [PDF]
, 2018 Enterotoxins increase intestinal fluid secretion through modulation of ion channels as well as activation of the enteric nervous and immune systems.
Gunasekara, Dulan B., Magness, Scott T.
core +3 more sources
Chronic Inflammation in Ulcerative Colitis Causes Long-Term Changes in Goblet Cell FunctionSummary
Cellular and Molecular Gastroenterology and Hepatology, 2022 Background & Aims: One of the features of ulcerative colitis (UC) is a defect in the protective mucus layer. This has been attributed to a reduced number of goblet cells (GCs).
Varsha Singh +10 more
doaj +1 more source