Results 71 to 80 of about 939 (180)

Intestinal epithelial ISG15 interactions with the immune system [PDF]

, 2022
Introduksjon Inflammatorisk tarmsykdom (IBD) er en tilstand med kronisk inflammasjon i gastrointestinal traktus som utgjøres av sykdommene Crohns sykdom og ulcerøs kolitt.
Walaas, Gunnar Andreas
core  

Intestinal epithelial pH-sensing receptor GPR65 maintains mucosal homeostasis via regulating antimicrobial defense and restrains gut inflammation in inflammatory bowel disease

Gut Microbes, 2023
Intestinal epithelial cell (IEC) regulation of barrier function and mucosal homeostasis enables the establishment of a harmonious gut microenvironment.
Gengfeng Li, Jian Lin, Xiang Gao, Huiling Su, Ritian Lin, Han Gao, Zhongsheng Feng, Huili Wu, Baisui Feng, Keqiang Zuo, Yingchuan Li, Wei Wu, Leilei Fang, Zhanju Liu   +13 more
doaj   +1 more source

Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection [PDF]

, 2020
Diarrhea caused by ...
Donowitz, Mark, Fleckenstein, James M, Foulke-Abel, Jennifer, Kaper, James B, Lin, Ruxian, Sunuwar, Laxmi, Yu, Huimin   +6 more
core   +2 more sources

Roles of Liquid Interface with Delicate Nanoarchitectonics for Molecular Recognition, Analysis, Reaction, Molecular Machine, Microrobot, and Life

ChemNanoMat, Volume 12, Issue 1, January 2026.
This review paper willdiscuss nanoarchitectonics at liquid interfaces. Topics covered will include molecular recognition, analytical methods, reactions controlled at liquid interfaces, control of molecular machines and microrobots, and regulation of biological phenomena using liquid interfaces. Overall, all of these processes require extremely delicate
Katsuhiko Ariga
wiley   +1 more source

Immune and Immune‐Integrated Organoids as NextGeneration Platforms for Disease Modeling

MedComm, Volume 6, Issue 12, December 2025.
This graphical abstract outlines the sources and methods for integrating immune cells into organoids. Immune cells can be derived from peripheral blood, tissues, or differentiated from human‐induced pluripotent stem cells. The immune cells are incorporated into the organoid by using coculture techniques, direct injection, as well as scaffolds and air ...
Kimiya Rashidan, Malaksima Ayadilord, Ali Hazrati, Amirhossein Nazerian, Abbas Shafiee, Seyed Mahmoud Hashemi   +5 more
wiley   +1 more source

Variant-to-Gene-Mapping Analyses Reveal a Role for the Hypothalamus in Genetic Susceptibility to Inflammatory Bowel DiseaseSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Inflammatory bowel disease (IBD) is a polygenic disorder characterized principally by dysregulated inflammation impacting the gastrointestinal tract. However, there also is increasing evidence for a clinical association with stress
Chiara Lasconi, Matthew C. Pahl, Diana L. Cousminer, Claudia A. Doege, Alessandra Chesi, Kenyaita M. Hodge, Michelle E. Leonard, Sumei Lu, Matthew E. Johnson, Chun Su, Reza K. Hammond, James A. Pippin, Natalie A. Terry, Louis R. Ghanem, Rudolph L. Leibel, Andrew D. Wells, Struan F.A. Grant   +16 more
doaj   +1 more source

Intestinal Organoids: New Frontiers in the Study of Intestinal Disease and Physiology. [PDF]

, 2022
The development of sustainable intestinal organoid cell culture has emerged as a new modality for the study of intestinal function and cellular processes. Organoid culture is providing a new testbed for therapeutic research and development.
Bayrer, James R, Wallach, Thomas E
core   +1 more source

Generation of Intestinal and Colonic Organoids Derived From Human Pluripotent Stem Cells

Biology of the Cell, Volume 117, Issue 12, December 2025.
Human pluripotent stem cells can be guided through a stepwise differentiation process to produce self‐organizing intestinal and colonic organoids. The resulting organoids recapitulate fetal‐stage epithelial and mesenchymal organization, offering a powerful model to explore human gastrointestinal development and its disorders.
Lola Bonneau, Lisa Brossard, Theo Noël, Victor Perreaux, Laura Bachir, Archie Khan, Simon Vales, Maxime M. Mahe   +7 more
wiley   +1 more source

A matter of differentiation: equine enteroids as a model for the in vivo intestinal epithelium

Veterinary Research
Epithelial damage due to gastrointestinal disorders frequently causes severe disease in horses. To study the underlying pathophysiological processes, we aimed to establish equine jejunum and colon enteroids (eqJE, eqCE) mimicking the in vivo epithelium ...
Christina Windhaber, Anna Heckl, Georg Csukovich, Barbara Pratscher, Iwan Anton Burgener, Nora Biermann, Franziska Dengler   +6 more
doaj   +1 more source

Enterohemorrhagic E. coli (EHEC)—Secreted Serine Protease EspP Stimulates Electrogenic Ion Transport in Human Colonoid Monolayers

Toxins, 2018
One of the characteristic manifestations of Shiga-toxin-producing Escherichia coli (E. coli) infection in humans, including EHEC and Enteroaggregative E. coli O104:H4, is watery diarrhea. However, neither Shiga toxin nor numerous components of the type-3
C. Ming Tse, Julie G. In, Jianyi Yin, Mark Donowitz, Michele Doucet, Jennifer Foulke-Abel, Fernando Ruiz-Perez, James P. Nataro, Nicholas C. Zachos, James B. Kaper, Olga Kovbasnjuk   +10 more
doaj   +1 more source