Results 81 to 90 of about 939 (180)
Cancer Medicine, Volume 14, Issue 13, July 2025.Iron chelation is a promising yet underexplored strategy for colorectal cancer (CRC) treatment. Iron chelators have a dual role in inhibiting and potentially promoting cancer progression. Iron chelation affects key CRC pathways, including histone methylation, NDRG1 upregulation, Wnt/β‐catenin, and p53 modulation.
Gihani Vidanapathirana +4 more
wiley +1 more source
Establishment of patient-derived enteroids/colonoids from endoscopic biopsies v1
, 2023 This protocol describes the full procedure of generating an enteroid or colonoid culture from endoscopic biopsy (either freshly procured or recovered from cryopreservation), was developed for human tissue, but works equally well for murine tissue fragments.
openaire +1 more source
Molecular Nutrition &Food Research, Volume 69, Issue 14, July 2025.Identifying health‐promoting molecules such as bioactive peptides in complex food mixtures is a major challenge. In this study, we investigated proteins and protein hydrolysates from four quinoa varieties to evaluate their potential anticancer effects on colorectal adenocarcinoma cells.
Alessandro Zaccarelli +6 more
wiley +1 more source
Cancer Medicine, 2020 Molecular‐targeted therapies have demonstrated disappointing results against most advanced solid cancers. This may largey be attributed to irrational drug use against unselected cancers.
Ashokkumar Dilly +4 more
doaj +1 more source
mBio, 2021 Multiple studies have implicated microbes in the development of inflammation, but the mechanisms remain unknown. Bacteria in the genus Fusobacterium have been identified in the intestinal mucosa of patients with digestive diseases; thus, we hypothesized ...
Melinda A. Engevik +16 more
doaj +1 more source
Creation of an In-Vitro Generated Colonic Stem-Cell Niche Using Gradient-Generating Microdevices [PDF]
, 2015 The limitations of existing cell culture and animal studies have provided an impetus for the development of alternative cell based in vitro models that better mimic the complex structures and functions of living organs.
Ahmad, Asad
core +2 more sources
The FASEB Journal, Volume 39, Issue 11, 15 June 2025.The complexity of indole‐3‐acetic acid's (IAA's) role in human health and disease. IAA is a multifaceted compound with significant consequences for several physiological and pathological processes. ABSTRACT Indole‐3‐acetic acid (IAA) is recognized as a common plant growth hormone.
Nargis Shaheen +4 more
wiley +1 more source
mBio, 2023 Enterohemorrhagic Escherichia coli (EHEC) is a highly adaptive pathogen and has acquired diverse genetic elements, such as genomic islands and prophages, via horizontal gene transfer to promote fitness in vivo.
Dawei Yang +8 more
doaj +1 more source
Culture media and format alter cellular composition and barrier integrity of porcine colonoid-derived monolayers [PDF]
Intestinal organoid technology has revolutionized our approach to in vitro cell culture due in part to their three-dimensional structures being more like the native tissue from which they were derived with respect to cellular composition and architecture.
Barnett AM +3 more
core +2 more sources
Engineered Tissue Models to Decode Host–Microbiota Interactions
Advanced Science, Volume 12, Issue 23, June 20, 2025.Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio +5 more
wiley +1 more source