Results 121 to 130 of about 141,334 (303)

Advances in therapeutics for liver metastasis from colorectal cancer

World Journal of Gastrointestinal Oncology, 2010
The evolution of chemotherapeutic regimens that include targeted molecular agents has resulted in a breakthrough in the management of advanced colorectal liver metastasis (CLM), improving the progression-free survival after liver resection, and rendering initially unresectable liver tumors resectable, with reported resection rates ranging from 13% to ...
Akira, Kobayashi, Shinichi, Miyagawa
openaire   +2 more sources

Multimodality Imaging of Tumour Pathophysiology and Response to Pharmacological Intervention

, 2015
This thesis describes the need for imaging the tumour pathophysiological microenvironment in order to understand response to treatment. Specifically looking at tumour vascularisation in in vivo murine xenograft models of disease, response to treatment ...
Johnson, SP
core  

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Repeat Hepatic Surgery for Colorectal Cancer Metastasis to the Liver

Annals of Surgery, 1996
The authors addressed whether a repeat hepatic operation is warranted in patients with recurrent isolated hepatic metastases. Are the results as good after second operation as after first hepatic operation?Five-year survival after initial hepatic operation for colorectal metastases is approximately 33%.
C W, Pinson, J K, Wright, W C, Chapman, C L, Garrard, T K, Blair, J L, Sawyers   +5 more
openaire   +3 more sources

miRNAs link metabolic reprogramming to oncogenesis

, 2013
The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Iliopoulos, D, Hatziapostolou, M, Polytarchou, C   +2 more
core   +1 more source

Nidogen 1-enriched extracellular vesicles promote liver metastasis by inducing EMT and activating stellate cells

iScience
Summary: The liver is frequently affected by metastasis in colorectal cancer patients; however, the precise interaction between the liver microenvironment and metastatic colorectal cancer cells remains elusive.
Haipeng Chen, Hengchang Liu, Lin Wang, Jialiang Liu, Tianli Chen, You Zuo, Hanqing Hu, Xishan Wang, Guiyu Wang   +8 more
doaj   +1 more source

Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level

BMC Cancer, 2008
Background Mortality from colorectal cancer is mainly due to metastatic liver disease. Improved understanding of the molecular events underlying metastasis is crucial for the development of new methods for early detection and treatment of colorectal ...
Hall David A, O'Connor Rosemary, Wiles Anna, Ward Teresa, Shi Hong-jun, Hood Kylie A, Macartney-Coxson Donia P, Lea Rod A, Royds Janice A, Stubbs Richard S, Rooker Serena   +10 more
doaj   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

Functional validation of cancer stem cell markers in primary human colorectal cancer and established cell lines [PDF]

, 2014
In an increasing number of cancers, CSCs have been defined on the basis of the self-renewal and tumor initiation capacity by functional assays. It has been also suggested that CSC populations might be responsible for chemo- and radio-therapy resistance ...
Muraro, Manuele Giuseppe
core   +1 more source

Clinical risk factors and survival analysis of postoperative recurrence or metastasis of colorectal cancer

BMC Cancer
Background Colorectal cancer is one of the malignant tumors, and postoperative recurrence or metastasis is a key factor to the survival of patients. Methods Patients who underwent colorectal cancer surgery between January 2016 and December 2020 were ...
Haoran Zhu, Yuankun Cai, ChongWei Ke, Huipeng Wang   +3 more
doaj   +1 more source