Results 141 to 150 of about 141,334 (303)

Partial hepatectomy accelerates colorectal metastasis by priming an inflammatory premetastatic niche in the liver

Frontiers in Immunology
BackgroundResection of colorectal liver metastasis is the standard of care for patients with Stage IV CRC. Despite undoubtedly improving the overall survival of patients, pHx for colorectal liver metastasis frequently leads to disease recurrence.
Jost Luenstedt, Jost Luenstedt, Fabian Hoping, Reinhild Feuerstein, Bernhard Mauerer, Bernhard Mauerer, Bernhard Mauerer, Christopher Berlin, Christopher Berlin, Christopher Berlin, Christopher Berlin, Julian Rapp, Julian Rapp, Lisa Marx, Wilfried Reichardt, Dominik von Elverfeldt, Dietrich Alexander Ruess, Dietrich Alexander Ruess, Dietrich Alexander Ruess, Dorothea Plundrich, Claudia Laessle, Andreas Jud, Hannes Philipp Neeff, Philipp Anton Holzner, Stefan Fichtner-Feigl, Stefan Fichtner-Feigl, Stefan Fichtner-Feigl, Rebecca Kesselring, Rebecca Kesselring, Rebecca Kesselring   +29 more
doaj   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

miR-455/GREM1 axis promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing M2 macrophage polarization

Cancer Cell International
Background Colorectal cancer is among the most common malignant tumors affecting the gastrointestinal tract. Liver metastases, a complication present in approximately 50% of colorectal cancer patients, are a considerable concern.
Shipeng Dai, Fan Xu, Xiaozhang Xu, Tian Huang, Yiming Wang, Hongyu Wang, Yucheng Xie, Lei Yue, Wenhu Zhao, Yongxiang Xia, Jian Gu, Xiaofeng Qian   +11 more
doaj   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

Advanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi, Jingrui Cao, Tong Wu, Guang Yang, YaWen Yang, Shixin Zhang, Wenwen Su, Hongyu Chu, Yangyang Zhao, Shan Jiang, Qiong Wu, Dongxu Jiao, Fangfang Chen   +12 more
wiley   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Prealbumin predicts metachronous liver metastasis in colorectal cancer

BMC Cancer
Predicting metachronous liver metastasis (MLM) in colorectal cancer (CRC) is crucial in clinical practice. Studies have shown that prealbumin is linked to recurrence and poor overall survival in various malignancies. This study aims to determine whether prealbumin levels can predict postoperative MLM in CRC patients.This study included both a primary ...
Xie, Han-bing, Zhang, Bei-bei, Zhao, Lin, Liu, Le, Liu, Ping-ping, Zhang, Xin, Miao, Shi-di, Wang, Rui-tao, Xu, Hai-tao   +8 more
openaire   +2 more sources

Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer

, 2018
Purpose: Tumors continuously evolve to maintain growth; secondary mutations facilitate this process, resulting in high tumor heterogeneity. In this study, we compared mutations in paired primary and metastatic colorectal cancer tumor samples to determine
오보영
core   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Liver metastasis of colorectal cancer

Russian Journal of Oncology, 2013
Yu. A Magarill, S. M Borzyanitsa
openaire   +1 more source