Results 131 to 140 of about 4,253,992 (294)

PDT-regulated immune gene prognostic model reveals tumor microenvironment in colorectal cancer liver metastases

Scientific Reports
Liver metastasis is the most common site of metastasis in colorectal cancer, and the prognosis of colorectal cancer patients with liver metastasis is extremely poor.
Jiachi Xu, Hui Zhou, Zhongtao Liu, Yunpeng Huang, Zijian Zhang, Heng Zou, Yongxiang Wang   +6 more
doaj   +1 more source

Hepatic Metastasis from Colorectal Cancer

, 2016
The liver is the most common site of metastasis in patients with colorectal cancer due to its anatomical situation regarding its portal circulation. About 14 to 18% of patients with colorectal cancer present metastasis at the first medical consultation ...
Eduardo E Montalvo-Javé, Alan I Valderrama-Treviño, Baltazar Barrera-Mera, Jesús C Ceballos-Villalva   +3 more
core   +1 more source

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

Advanced Science, EarlyView.
An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu, Yingyu Zhang, Xianwei Zhang, Mengxin Zhang, Fei Zhang, Jushan Sun, Yahui Yang, Kangbo Liu, Peng Wang, Shuying Luo, Wancun Zhang   +10 more
wiley   +1 more source

Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis

Journal of Translational Medicine
Background Colorectal cancer (CRC) exhibits a high incidence globally, with the liver being the most common site of distant metastasis. At the time of diagnosis, 20–30% of CRC patients already present with liver metastases.
Linfeng Sun, Xiangdong Li, Yuhao Xiao, Wenjie Yu, Xuyang Chen, Ziyi Wang, Nan Xia, Xuejiao Chen, Minhao Chen, Haoliang Zhu, Jie Li, Jie Wei, Sheng Han, Liyong Pu   +13 more
doaj   +1 more source

Pulmonary metastasectomy in colorectal cancer patients with previously resected liver metastasis: pooled analysis.

, 2015
Data addressing the outcomes and patterns of recurrence after pulmonary metastasectomy (PM) in patients with colorectal cancer (CRC) and previously resected liver metastasis are ...
Massad, E., Hamed, O.H., Toubasi, Samar, Hamed, Osama H, Salah, Samer, Zabaleta, Jon, Massad, Ehab, Lisi, Elena, Salah, S., Ardissone, F., Toubasi, S., Gervaz, Pascal, Riquet, Marc, Ardissone, Francesco, Lisi, E., Al-Rimawi, Dalia, Al-Rimawi, D., Gervaz, P., Riquet, M., Gonzalez, M., Watanabe, K., Gonzalez, Michel, Watanabe, Kazuhiro, Zabaleta, J.   +23 more
core   +1 more source

Topological Quantum Biomaterials Enable Pyroptosis‐Senescence Coupling for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
This work reports conceptually unprecedented topological quantum biomaterials derived from engineered Pd3Sn nanostrips for oncological applications. Their near‐Fermi‐level electronic architecture and superior interfacial charge transport facilitate ultrasound‐amplified redox reactions and efficient ROS generation.
Zilu Chen, Kun Mei, Yan Yang, Mengna Xu, Xinyue Dai, Renjun Gu, Fuqiong Zhou, Cheng Wang, Meiqi Chang, Yan Huang, Yu Chen   +10 more
wiley   +1 more source

Overexpression of Extracellular Superoxide Dismutase 3 Inhibits Cancer Cell Growth and Migration in Colorectal Cancer

The Turkish Journal of Gastroenterology
Background/Aims: Incidence of colorectal cancer is rapidly increasing worldwide. Extracellular superoxide dismutase (EcSOD; SOD3) is an antioxidant enzyme. However, SOD3 roles in colorectal cancer progression remain uncertain.
Donghua Wang, Manyu Chen, Zhenggui Tao, Jinghu Du, Kui Tian, Zhen Chen, Bo Yu, Yu Chen, Long Lv   +8 more
doaj   +1 more source

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

The DNA Repair Inhibitor DT01 as a Novel Therapeutic Strategy for Chemosensitization of Colorectal Liver Metastasis

, 2016
International audienceAbstract Metastatic liver disease from colorectal cancer is a significant clinical problem. This is mainly attributed to nonresectable metastases that frequently display low sensitivities to available chemotherapies and develop drug
Lienafa, Marie-Christine, Dutreix, Marie, Denys, Alban, Herath, Nirmitha, Sun, Jian-Sheng, Devun, Flavien, Herbette, Aurélie, Denys A, Dutreix M, Devun F, Devun, F., Herbette A, Herath NI, Dutreix, M., Lienafa MC, Sun JS, Herath, N.I., Herbette, A., Lienafa, M.C., Denys, A., Sun, J.S.   +20 more
core   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source