Results 131 to 140 of about 1,880,046 (331)

Poly(amino acid) Synthesis from 2,5‐Diketopiperazines for Acid‐Actuated Drug Release

Macromolecular Materials and Engineering
Poly(amino acids) have enormous potential value as biomaterials owing to their inherent biocompatibility, chemical functionality, and biodegradability. However, current commercial poly(amino acid) use is somewhat limited due to production protocols that ...
Patrick A. Wall, Charlie O. H. Sajid, Karen Mitchinson, Paul D. Thornton   +3 more
doaj   +1 more source

Bioactive and agroindustrial potential of Amazonian fruit species: a review

Cogent Food & Agriculture
Its high biodiversity makes the Amazon rainforest a strategic place to carry out bioprospecting of fruit and plant species with nutritional, biofunctional, and technological value.
Liceth Natalia Cuéllar Álvarez, Juliana María García-Chacón, Francisco J. Heredia, M. Lourdes González-Miret   +3 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Colour Tests for the Detection and Characterisation of Tertiary Amines. [PDF]

, 1966
Arne B. Groth, Gun Wallerberg, Gustav Schroll, J. H. Bowie, D. H. Williams, E. Bunnenberg, Carl Djerassi, Ruth Records   +7 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Bioactive Lipophilic Antioxidants (Carotenoids, Tocols, Retinol, and Coenzyme Q₁₀) in Human and Animal Tissues: Development and Validation of a Rapid Extraction and Chromatographic Method for Nutrition and Health Studies

Antioxidants
A rapid and robust analytical method was validated for the simultaneous extraction and quantification of carotenoids and other lipophilic antioxidants (tocopherols, tocotrienols, retinol and coenzyme Q10) in human and animal tissues using a tandem RRLC ...
Ana M. Benítez-González, Carla M. Stinco, Mladen Brnčić, Francisco J. Barba, Antonio J. Meléndez-Martínez   +4 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Colour segmentation of multi variants tuberculosis sputum images using self organizing map

, 2017
Riries Rulaningtyas, Andriyan Bayu Suksmono, Tati L. R. Mengko, Putri Saptawati   +3 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source