Results 91 to 100 of about 3,531,799 (287)
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
A column generation approach to solve the crew re-scheduling problem [PDF]
When tracks are out of service for maintenance during a certainperiod, trains cannot be operated on those tracks. This leads to amodified timetable, and results in infeasible rolling stock andcrew schedules. Therefore, these schedules need to be repaired.
Huisman, D.
core
Dynamic Generation of Cutting Patterns in Sawmills for Sustainable Planning
MathematicsThis study proposes two optimization models and a column-generation algorithm, applied at the root node, to support tactical planning in sawmills by dynamically generating log cutting patterns aligned with sustainability and efficiency objectives ...
Jorge Félix Mena-Reyes +3 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
IEEE Open Journal of the Communications SocietyUnmanned aerial vehicle (UAV) operations are creating diverse application scenarios with the development of sixth-generation (6G) mobile networks. Consequently, low-altitude airspace surveillance has become a critical issue for public security.
Shaochuan Zhu +4 more
doaj +1 more source
A hybrid column generation algorithm based on metaheuristic optimization
Transport, 2016 The exact solution and heuristic solution have their own strengths and weaknesses on solving the Vehicle Routing Problems with Time Windows (VRPTW).
Wenbin Hu +5 more
doaj +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Speeding up column generation for robust wireless network planning
EURO Journal on Computational Optimization, 2013 The wireless network planning problem consists of base station placement and traffic node assignment to base stations. To incorporate traffic demand uncertainties, we follow the Γ-robustness approach by Bertsimas and Sim.
Grit Claßen +2 more
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source