Results 101 to 110 of about 451,802 (301)
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Abstract This chapter describes the classical column generation algorithm used to solve a linear program with a huge number of variables. Besides its main properties, we offer several practical hints to be included in any worthwhile implementation and present a few classical examples of its application.
Jacques Desrosiers +3 more
openaire +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Reformulation and decomposition of integer programs [PDF]
In this survey we examine ways to reformulate integer and mixed integer programs. Typically, but not exclusively, one reformulates so as to obtain stronger linear programming relaxations, and hence better bounds for use in a branch-and-bound based ...
WOLSEY , Laurence +1 more
core
Bus driver rostering by column generation metaheuristics
, 2016 In the Bus Driver Rostering Problem (BDRP) it is intended to define work schedules for workers such that costs are minimized. This problem has been addressed before by combining column generation and an evolutionary algorithm.
Barbosa, Vítor +5 more
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
All-integer column generation: Basic principles and extensions
, 2014 Column generation is a linear programming method in which a dual solution of the master problem is essential when deriving new columns by solving a subproblem.
Larsson, Torbjörn +3 more
core +1 more source
Annealing-Assisted Column Generation for Inequality-Constrained Combinatorial Optimization Problems
IEEE AccessIsing machines are expected to solve combinatorial optimization problems faster than the existing integer programming solvers. These problems, particularly those encountered in practical situations, typically involve inequality constraints.
Hiroshi Kanai +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source