Results 81 to 90 of about 451,802 (301)

Branch-and-price-and-cut for large-scale multicommodity capacitated fixed-charge network design

EURO Journal on Computational Optimization, 2014
We present a branch-and-price-and-cut algorithm for solving large-scale instances of the multicommodity capacitated fixed-charge network design problem.
Bernard Gendron, Mathieu Larose
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Column Generation for the Split Delivery VRP [PDF]

In this paper we tackle a variation of the Vehicle Routing Problem (VRP) in which each customer can be served by more than one vehicle, each serving a fraction of its demand. This problem is known as the Split Delivery VRP (SDVRP).
Salani, Matteo, Ceselli, Alberto
core  

A Column-Generation-Based Exact Algorithm to Solve the Full-Truckload Vehicle-Routing Problem

Mathematics
This study addresses a specialized variant of the full-truckload delivery problem inspired by a Turkish logistics firm that operates in the liquid transportation sector.
Toygar Emre, Rizvan Erol
doaj   +1 more source

Generation of Plug-like Chromatographic Bands in Preparative Liquid Chromatographic Column by Using Conical Shape Wall Column.

, 2008
Generation of Plug-like Chromatographic Bands in Preparative Liquid Chromatographic Column by Using Conical Shape Wall ...
关亚风, 陈捷, 卢烈娟
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A patterning algorithm for the dynamic bin packing problem with placement groups

Моделирование и анализ информационных систем
We consider an NP-hard problem of dynamically distributing virtual machines to servers with placement groups. For each virtual machine, parameters such as required number of resources and creation and deletion timestamps are known.
Evgeniy A. Brazhnikov, Artem A. Panin, Alexey V. Ratushnyi   +2 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Two-stage column generation ∗ [PDF]

, 2010
We introduce a new concept in column generation for handling complex large scale optimization problems, called two-stage column generation, where columns for the compact and extensive formula-tion are simultaneously generated.
Michel Bierlaire, Vacca, Ilaria, Salani, Matteo, Matteo Salani, Bierlaire, Michel, Ilaria Vacca   +5 more
core  

Combinatorial Robust Optimization with Decision-Dependent Information Discovery and Polyhedral Uncertainty

Open Journal of Mathematical Optimization
Given a nominal combinatorial optimization problem, we consider a robust two-stages variant with polyhedral cost uncertainty, called Decision-Dependent Information Discovery (DDID). In the first stage, DDID selects a subset of uncertain cost coefficients
Omer, Jérémy, Poss, Michael, Rougier, Maxime   +2 more
doaj   +1 more source