Results 61 to 70 of about 3,531,799 (287)

Column generation in the integral simplex method

European Journal of Operational Research, 2009
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Elina Rönnberg, Torbjörn Larsson
openaire   +4 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Vectorwise: Beyond Column Stores [PDF]

, 2012
This paper tells the story of Vectorwise, a high-performance analytical database system, from multiple perspectives: its history from academic project to commercial product, the evolution of its technical architecture, customer reactions to the product ...
Zukowski, Marcin, Zukowski, M. (Marcin), Boncz, P.A. (Peter), Boncz, P.A., Boncz, P.A.; id_orcid, Zukowski, M., Boncz, Peter   +6 more
core   +2 more sources

A column generation algorithm for nonlinear programming [PDF]

Mathematical Programming, 1973
An algorithm using column generation and penalty function techniques is presented. A linear program with a uniformly bounded number of columns, similar to the restricted master in generalized programming, is used to reduce the number of constraints included in forming a penalty function.
openaire   +3 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Integrated Optimization of Bunker–Cargo Trade-Offs in Tramp Ship Routing and Scheduling

Applied Sciences
This paper studies an integrated planning problem in tramp shipping operations, with a particular focus on the bunker–cargo trade-off in maritime logistics.
Lingrui Kong, Xiankang Zheng, Feng Wang, Wenwen Guo, Mingjun Ji   +4 more
doaj   +1 more source

Optimizing Train Formation Problem With Car Flow Routing and Train Routing by Benders-and-Price Approach

IEEE Access, 2019
As the core of the rail freight flow organization process, train formation problem (TFP) has attracted much attention. In Chinese practice, car flow routing, TFP, and train routing are usually optimized sequentially to reduce the complexity of ...
Zekang Lan, Shiwei He, Yan Xu, Yidong Wang   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Data-Driven Distributionally Robust Optimization for Elective Operating Room Allocation Under Moment-Based Ambiguity Sets: Exact Reformulations and a Column Generation Approach

Mathematics
Allocating elective patients to operating rooms (ORs) under uncertain surgery durations and limited historical data requires balancing, opening costs against overtime risk.
Jianfeng Ren, Yingying Jia, Guo Sun
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source