Results 51 to 60 of about 3,531,799 (287)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Chvátal–Gomory Cuts Applied to the Nurse Rostering Problem
SystemsThe nurse rostering problem (NRP) has attracted significant research interest in recent decades due to both its practical relevance and computational complexity.
Yuanyuan Fang, Wanzhe Hu, Li Luo
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Optimizing Bus Driver Scheduling: A Set Covering Approach for Reducing Transportation Costs
Applied System InnovationCutting operational costs is a critical component for transportation agencies. To reduce these costs, agencies must optimize their scheduling. Typically, the total operating costs of transport include vehicle expenses and driver wages. Solving such tasks
Viktor Sándor Árgilán +1 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Production, 2003 A localização de p-medianas é um problema clássico de otimização combinatória. O objetivo é localizar em uma rede p nós (denominados medianas), de forma a minimizar a soma das distâncias de cada nó de demanda até sua mediana mais próxima.
Edson Luiz França Senne +1 more
doaj +1 more source
Energy Reports, 2023 Model predictive control is an effective approach for microgrid energy management. However, the main downside of such method is its expensive online computational cost, which is not amenable to most practical microgrid implementations.
Yuchong Huo +3 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
A Constraint Programming based column generation approach to nurse rostering problems
, 2012 This paper presents our investigations on a hybrid constraint programming based column generation (CP–CG) approach to nurse rostering problems. We present a complete model to formulate all the complex real-world constraints in several benchmark nurse ...
He, F., Qu, R.
core +1 more source