Results 51 to 60 of about 451,802 (301)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Optimizing Bus Driver Scheduling: A Set Covering Approach for Reducing Transportation Costs
Applied System InnovationCutting operational costs is a critical component for transportation agencies. To reduce these costs, agencies must optimize their scheduling. Typically, the total operating costs of transport include vehicle expenses and driver wages. Solving such tasks
Viktor Sándor Árgilán +1 more
doaj +1 more source
Production, 2003 A localização de p-medianas é um problema clássico de otimização combinatória. O objetivo é localizar em uma rede p nós (denominados medianas), de forma a minimizar a soma das distâncias de cada nó de demanda até sua mediana mais próxima.
Edson Luiz França Senne +1 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
A Constraint Programming based column generation approach to nurse rostering problems
, 2012 This paper presents our investigations on a hybrid constraint programming based column generation (CP–CG) approach to nurse rostering problems. We present a complete model to formulate all the complex real-world constraints in several benchmark nurse ...
He, F., Qu, R.
core +1 more source
An enhanced concave program relaxation for choice network revenue management [PDF]
, 2013 The network choice revenue management problem models customers as choosing from an offer set, and the firm decides the best subset to offer at any given moment to maximize expected revenue.
Meissner, Joern +5 more
core +1 more source
Optimization Models for Reducing Off-Cuts of Raw Materials in Construction Site
Mathematics, 2022 More than ten billion tons of construction waste are generated every year in the world. The large volume of construction waste not only increases costs for contractors, but also poses a threat to the environment.
Haoqing Wang, Wen Yi
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source