Results 41 to 50 of about 440,308 (260)

Energy Efficient Resource Allocation in Cloud Computing Environments

IEEE Access, 2016
Power consumption is one of the major concerns for the cloud providers. The issue of disorganized power consumption can be categorized into two main groups: one caused by server operations and one occurred during the network communications. In this paper,
Shahin Vakilinia, Behdad Heidarpour, Mohamed Cheriet   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Learning assisted column generation for model predictive control based energy management in microgrids

Energy Reports, 2023
Model predictive control is an effective approach for microgrid energy management. However, the main downside of such method is its expensive online computational cost, which is not amenable to most practical microgrid implementations.
Yuchong Huo, Zaiyu Chen, Jing Bu, Minghui Yin   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Chvátal–Gomory Cuts Applied to the Nurse Rostering Problem

Systems
The nurse rostering problem (NRP) has attracted significant research interest in recent decades due to both its practical relevance and computational complexity.
Yuanyuan Fang, Wanzhe Hu, Li Luo
doaj   +1 more source

Abordagens complementares para problemas de p-medianas Complementary approaches for p-median location problems

Production, 2003
A localização de p-medianas é um problema clássico de otimização combinatória. O objetivo é localizar em uma rede p nós (denominados medianas), de forma a minimizar a soma das distâncias de cada nó de demanda até sua mediana mais próxima.
Edson Luiz França Senne, Luiz Antonio Nogueira Lorena   +1 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Optimizing Bus Driver Scheduling: A Set Covering Approach for Reducing Transportation Costs

Applied System Innovation
Cutting operational costs is a critical component for transportation agencies. To reduce these costs, agencies must optimize their scheduling. Typically, the total operating costs of transport include vehicle expenses and driver wages. Solving such tasks
Viktor Sándor Árgilán, József Békési   +1 more
doaj   +1 more source