Results 71 to 80 of about 3,531,799 (287)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Combining Column Generation and Lagrangian Relaxation [PDF]
Although the possibility to combine column generation and Lagrangian relaxation has been known for quite some time, it has only recently been exploited in algorithms. In this paper, we discuss ways of combining these techniques.
Jans, R.F. +3 more
core
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Bus driver rostering by hybrid methods based on column generation
, 2018 Tese de doutoramento, Informática (Engenharia Informática), Universidade de Lisboa, Faculdade de Ciências, 2018Rostering problems arise in a diversity of areas where, according to the business and labor rules, distinct variants of the problem are ...
Barbosa, Vítor
core
Numerical comparison of pipe-column-separation models [PDF]
, 1994 Results comparing six column-separation numerical models for simulating localized vapor cavities and distributed vaporous cavitation in pipelines are presented.
Bergant, A., Simpson, A.
core +1 more source
Column-generation PM2.5 prediction based on image mixture kernel
工程科学学报, 2020 The conventional method of PM2.5 prediction requires high-precision instruments to obtain data on the concentration of pollutants, resulting in a high prediction costs. In this work, we attempt to use image data to estimate PM2.5 concentration.
Xiao-li LI, Bo ZHANG, Xu YANG
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Column generation approaches to ship scheduling with flexible cargo sizes [PDF]
We present a Dantzig-Wolfe procedure for the ship scheduling problem with flexible cargo sizes. This problem is similar to the well-known pickup and delivery problem with time windows, but the cargo sizes are defined by an interval instead of a fixed ...
Nygreen, Bjørn +2 more
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Column Generation for the Split Delivery VRP [PDF]
In this paper we tackle a variation of the Vehicle Routing Problem (VRP) in which each customer can be served by more than one vehicle, each serving a fraction of its demand. This problem is known as the Split Delivery VRP (SDVRP).
Salani, Matteo, Ceselli, Alberto
core +1 more source