Results 61 to 70 of about 1,530,542 (289)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A Coordinated Optimization of Rewarded Users and Employees in Relocating Station–Based Shared Electric Vehicles

open access: yesInternational Journal of Applied Mathematics and Computer Science, 2022
To solve the mismatch between the supply and demand of shared electric vehicles (SEVs) caused by the uneven distribution of SEVs in space and time, an SEV relocating optimization model is designed based on a reward mechanism.
Yu Lan, Liu Jiaming, Sun Zhuo
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Maximum Variance Hashing via Column Generation [PDF]

open access: yesMathematical Problems in Engineering, 2013
With the explosive growth of the data volume in modern applications such as web search and multimedia retrieval, hashing is becoming increasingly important for efficient nearest neighbor (similar item) search. Recently, a number of data-dependent methods have been developed, reflecting the great potential of learning for hashing.
Luo, Lei   +3 more
openaire   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Optimizing Train Formation Problem With Car Flow Routing and Train Routing by Benders-and-Price Approach

open access: yesIEEE Access, 2019
As the core of the rail freight flow organization process, train formation problem (TFP) has attracted much attention. In Chinese practice, car flow routing, TFP, and train routing are usually optimized sequentially to reduce the complexity of ...
Zekang Lan   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Optimized shunting with mixed-usage tracks [PDF]

open access: yes, 2013
We consider the planning of railway freight classification at hump yards, where the problem involves the formation of departing freight train blocks from arriving trains subject to scheduling and capacity constraints.
Bohlin, Markus   +4 more
core   +1 more source

Observation of localized modes at phase slips in two-dimensional photonic lattices

open access: yes, 2010
We study experimentally light localization at phase-slip waveguides and at the intersection of phase-slips in a two-dimensional (2D) square photonic lattice.
Alexander Szameit   +24 more
core   +3 more sources

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