Results 71 to 80 of about 1,530,542 (289)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Searching for optimal integer solutions to set partitioning problems using column generation [PDF]
, 2007 We describe a new approach to produce integer feasible columns to a set partitioning problem directly in solving the linear programming (LP) relaxation using column generation. Traditionally, column generation is aimed to solve the LP relaxation as quick
Bredström, David +2 more
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
A Column Generation Approach Based on Region Growth
IEEE Access, 2019 In intensity-modulated radiation therapy (IMRT), a network flow is adopted to solve the pricing problem of the generic column generation approach in order to obtain a deliverable aperture.
Liyuan Zhang +3 more
doaj +1 more source
Column-generation PM2.5 prediction based on image mixture kernel
工程科学学报, 2020 The conventional method of PM2.5 prediction requires high-precision instruments to obtain data on the concentration of pollutants, resulting in a high prediction costs. In this work, we attempt to use image data to estimate PM2.5 concentration.
Xiao-li LI, Bo ZHANG, Xu YANG
doaj +1 more source
Dust obscuration studies along quasar sight lines using simulated galaxies
, 2003 We use the results of a set of three-dimensional SPH-Treecode simulations which model the formation and early evolution of disk galaxies, including the generation of heavy elements by star formation, to investigate the effects of dust absorption in ...
Churches, D. K. +2 more
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Branch-and-price-and-cut for large-scale multicommodity capacitated fixed-charge network design
EURO Journal on Computational Optimization, 2014 We present a branch-and-price-and-cut algorithm for solving large-scale instances of the multicommodity capacitated fixed-charge network design problem.
Bernard Gendron, Mathieu Larose
doaj +1 more source
The Single Period Coverage Facility Location Problem: Lagrangean heuristic and column generation approaches [PDF]
, 2010 In this paper we introduce the Single Period Coverage Facility Location Problem. It is a multi-period discrete location problem in which each customer is serviced in exactly one period of the planning horizon.
Albareda Sambola, María +3 more
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source