Results 81 to 90 of about 1,530,542 (289)
The Column Generation Technique for Public Transport Line Planning by IP-Solver
Communications, 2010 The paper deals with an application of the column generation method to the public transport line planning making use of a common optimization environment.
Jaroslav Janacek, Jan Sirc
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
A Column-Generation-Based Exact Algorithm to Solve the Full-Truckload Vehicle-Routing Problem
MathematicsThis study addresses a specialized variant of the full-truckload delivery problem inspired by a Turkish logistics firm that operates in the liquid transportation sector.
Toygar Emre, Rizvan Erol
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Audit-Staff Scheduling by Column Generation [PDF]
, 2007 When scheduling its audit-staff, the management of an auditing firm encompasses a number of decisions. These may be grouped into several categories which differ markedly in terms of organizational echelon involved, length of the planning horizon and the planning periods, degree of aggregation of the audit tasks, degree of detail of the required ...
Drexl, Andreas +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
A patterning algorithm for the dynamic bin packing problem with placement groups
Моделирование и анализ информационных системWe consider an NP-hard problem of dynamically distributing virtual machines to servers with placement groups. For each virtual machine, parameters such as required number of resources and creation and deletion timestamps are known.
Evgeniy A. Brazhnikov +2 more
doaj +1 more source
A hybrid column generation algorithm based on metaheuristic optimization
Transport, 2016 The exact solution and heuristic solution have their own strengths and weaknesses on solving the Vehicle Routing Problems with Time Windows (VRPTW).
Wenbin Hu +5 more
doaj +1 more source
Combining Column Generation and Lagrangian Relaxation [PDF]
Although the possibility to combine column generation and Lagrangian relaxation has been known for quite some time, it has only recently been exploited in algorithms. In this paper, we discuss ways of combining these techniques.
Huisman, D. +3 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Open Journal of Mathematical OptimizationGiven a nominal combinatorial optimization problem, we consider a robust two-stages variant with polyhedral cost uncertainty, called Decision-Dependent Information Discovery (DDID). In the first stage, DDID selects a subset of uncertain cost coefficients
Omer, Jérémy +2 more
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