Results 61 to 70 of about 2,566,141 (344)

Self-protected electrodes limit field-emission current [PDF]

, 1975
One cathode includes array of square-shaped conductor columns. Columns are electrically interconnected by conducting plate on bottom. Each column provides field-emission current. Another cathode includes array of rodlike conductors.
Lees, W. L.
core   +1 more source

Time-Dependent Deformations of Eccentrically Loaded Reinforced Concrete Columns

International Journal of Concrete Structures and Materials, 2018
If reinforced concrete columns and walls in high-rise buildings are subjected to axial load for a sustained duration, long-term lateral deformation (or curvature) as well as axial shortening increase over time due to the creep and shrinkage of concrete ...
Tae-Sung Eom, Chang-Soo Kim, Xin Zhang, Jae-Yo Kim   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Limited column formation in the embryonic growth plate implies divergent growth mechanisms during pre- and postnatal bone development

eLife
Chondrocyte columns, which are a hallmark of growth plate architecture, play a central role in bone elongation. Columns are formed by clonal expansion following rotation of the division plane, resulting in a stack of cells oriented parallel to the growth
Sarah Rubin, Ankit Agrawal, Anne Seewald, Meng-Jia Lian, Olivia Gottdenker, Paul Villoutreix, Adrian Baule, Tomer Stern, Elazar Zelzer   +8 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Mathematical modeling of thermal stabilization of vertical wells on high performance computing systems

, 2013
Temperature stabilization of oil and gas wells is used to ensure stability and prevent deformation of a subgrade estuary zone. In this work, we consider the numerical simulation of thermal stabilization using vertical seasonal freezing columns.
Pavlova, Natalia V., Vabishchevich, Petr N., Vasilyeva, Maria V.   +2 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Stratigraphic columns and correlations for the Late Eocene - Oligocene Te Kuiti Group, central-western North Island, New Zealand [PDF]

, 2008
This report presents a compilation of stratigraphic columns for geological sections and outcrops of Late Eocene – Oligocene Te Kuiti Group units in central-western parts of North Island, New Zealand, between Port Waikato and Awakino.
Kamp, Peter J.J., Nelson, Campbell S., Tripathi, Anand Ratnakar Prasad   +2 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source