Results 31 to 40 of about 28,100,614 (312)

The effect of Chinese herbal formulas combined with metformin on modulating the gut microbiota in the amelioration of type 2 diabetes mellitus: A systematic review and meta-analysis

Frontiers in Endocrinology, 2022
To assess and analyse the effectiveness and safety of combined Chinese herbal formula (CHF) and metformin treatment in the modulation of the gut microbiota in the amelioration of type 2 diabetes mellitus(T2DM), all publications addressing the effect of ...
Yunxi Xu, Shuyu Zheng, Shui Jiang, Junyu Chen, Xiaofang Zhu, Ya Zhang   +5 more
doaj   +1 more source

Levistolide A and periplogenin inhibit the growth of gastric cancer cells in vitro and in vivo [PDF]

Exploration of Drug Science, 2023
Aim: In the present study, the natural products levistolide A (LA) and periplogenin (PPG) were studied for their growth inhibitory effects on the development of gastric cancer cells in vitro and, more critically, in vivo, alone or in combination with the
Jia Li Guo, Hong Mei Hu, Shao Chin Lee, Ji Zhong Zhao   +3 more
doaj   +1 more source

Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children. [PDF]

, 2008
BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with implications for changes in treatment policy.
Pinoges Loretxu, Balkan, S, Grant Dorsey, Pinoges, Loretxu, Hasifa Burkirwa, Olliaro, P, Pedro Pablo Palma Urruta, Checchi, Francesco, Ingrid van den Broek, Dorsey Grant, Urruta, P P P, Walter R Taylor, Michel van Herp, Ashley Elizabeth A, Dorsey, G, van Herp Michel, Turyakira, Eleanor, Guthmann, Jean-Paul, Ashley, Elizabeth A, Zongo Issaka, Taylor Walter R, van Herp, M, Francesco Checchi, Issaka Zongo, Turyakira, E, Zongo, I, Taylor, W R J, Balkan Suna, Dorsey, Grant, van den Broek Ingrid, van Herp, Michel, Ashley, E A, van den Broek, Ingrid, Taylor, Walter R, Urruta, Pedro Pablo Palma, Elizabeth A Ashley, Eleanor Turyakira, Olliaro Piero, Pinoges, L, Jean-Paul Guthmann, Guthmann, J P, Guthmann Jean-Paul, van den Broek, I, Piero Olliaro, Zongo, Issaka, Checchi Francesco, Bukirwa, H, Checchi, F, Loretxu Pinoges, Bukirwa, Hasifa, Turyakira Eleanor, Suna Balkan, Bukirwa Hasifa, Urruta Pedro, Balkan, Suna, Olliaro, Piero   +55 more
core   +1 more source

Single‐cell profiling‐guided combination therapy of c‐Fos and histone deacetylase inhibitors in diffuse large B‐cell lymphoma

Clinical and Translational Medicine, 2022
Background Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin lymphoma. Histone deacetylase inhibitors (HDACis) have been widely applied in multiple tumours, but the expected efficacy was not observed in DLBCL.
Luqiao Wang, Zijuan Wu, Yi Xia, Xueying Lu, Ji Li, Lei Fan, Chun Qiao, Hairong Qiu, Danling Gu, Wei Xu, Jianyong Li, Hui Jin   +11 more
doaj   +1 more source

Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children. [PDF]

, 2008
BACKGROUND: Combination antimalarial therapy is recommended for the treatment of uncomplicated falciparum malaria in Africa; however, some concerns about the safety and tolerability of new regimens remain.
Njama-Meya Denise, Staedke Sarah G, Catherine Maiteki-Sebuguzi, Denise Njama-Meya, Moses R Kamya, Sarah G Staedke, Maiteki-Sebuguzi Catherine, Grant Dorsey, Yau, Vincent M, Jagannathan, Prasanna, Dorsey, Grant, Talisuna, Ambrose O, Dorsey Grant, Ambrose O Talisuna, Rosenthal Philip J, Jagannathan Prasanna, Maiteki-Sebuguzi, Catherine, Rosenthal, Philip J, Tamara D Clark, Clark Tamara D, Nzarubara Bridget, Staedke, Sarah G, Prasanna Jagannathan, Yau Vincent M, Nzarubara, Bridget, Vincent M Yau, Philip J Rosenthal, Njama-Meya, Denise, Clark, Tamara D, Kamya Moses R, Bridget Nzarubara, Kamya, Moses R, Talisuna Ambrose O   +32 more
core   +1 more source

Xinmai 'an extract enhances the efficacy of sildenafil in the treatment of pulmonary arterial hypertension via inhibiting MAPK signalling pathway

Pharmaceutical Biology, 2021
Context Xinmai 'an tablet has been used to improve myocardial blood supply. Recently, some compounds from its formula have shown that they can treat pulmonary arterial hypertension (PAH).
Yaolu Zhu, Yabin Sun, Shichang Zhang, Chuyuan Li, Yiwei Zhao, Boxin Zhao, Guofeng Li   +6 more
doaj   +1 more source

Azithromycin plus chloroquine: combination therapy for protection against malaria and sexually transmitted infections in pregnancy. [PDF]

, 2011
INTRODUCTION: The first-line therapy for the intermittent preventive treatment of malaria in pregnancy (IPTp) is sulphadoxine-pyrimethamine (SP).
Chandramohan, Daniel, Chico, R Matthew, Daniel Chandramohan, R Matthew Chico   +3 more
core   +1 more source

The costs of introducing artemisinin-based combination therapy: evidence from district-wide implementation in rural Tanzania. [PDF]

, 2008
BACKGROUND\ud \ud The development of antimalarial drug resistance has led to increasing calls for the introduction of artemisinin-based combination therapy (ACT).
Goodman Catherine A, Mulligan Jo, Abdulla, Salim, Bloland, Peter, McHomvu, Naiman, Mills, Anne, Mills Anne, Mchomvu Naiman, Munkondya John S, Njau Joseph D, Abdulla Salim, Munkondya, John S, Bloland Peter, Kachur, S Patrick, Njau, Joseph D, Goodman, Catherine A, Kachur S Patrick, Mulligan, Jo   +17 more
core   +1 more source

Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria : a literature review and meta-analysis of individual patient data [PDF]

, 2015
Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong sub-region and poses a major global public health threat. Slow parasite clearance is a key clinical manifestation of reduced susceptibility to artemisinin.
Wwarn Artemisinin based Combination Therapy Africa Baseline Stud,
core   +1 more source

Combination treatment with radiotherapy and a novel oxidative phosphorylation inhibitor overcomes PD-1 resistance and enhances antitumor immunity

Journal for ImmunoTherapy of Cancer, 2020
Background Despite outstanding responses to anti-PD-1 agents in a subset of non-small cell lung cancer (NSCLC) patients, approximately 80% of patients fail to have prolonged favorable response.
Dawei Chen, H. Barsoumian, Grant M. Fischer, Liang-Peng Yang, V. Verma, A. Younes, Yun Hu, Fatemeh Masropour, K. Klein, C. Vellano, J. Marszalek, M. Davies, M. Cortez, J. Welsh   +13 more
semanticscholar   +1 more source